Results 111 to 120 of about 383,770 (381)

Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex

Journal of Cell Biology, 2015
VE-cadherin plays a critical role in endothelial shear stress mechanotransduction by interacting with VEGFRs through their transmembrane domains.
Brian G. Coon, Nicolas Baeyens, Jinah Han, Madhusudhan Budatha, T. Ross, Jennifer S. Fang, Sanguk Yun, Jeon-Leon Thomas, M. Schwartz   +8 more
semanticscholar   +1 more source

MagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells

Advanced Functional Materials, EarlyView.
MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández, Mariarosaria De Simone, Yilian Fernández‐Afonso, Daniel Garcia‐Gonzalez, Pablo Martínez‐Vicente, Thomas van Zanten, Raluca M. Fratila, Maria Moros   +7 more
wiley   +1 more source

Pre-metazoan origins and evolution of the cadherin adhesome

Biology Open, 2014
Vertebrate adherens junctions mediate cell–cell adhesion via a “classical” cadherin–catenin “core” complex, which is associated with and regulated by a functional network of proteins, collectively named the cadherin adhesome (“cadhesome”). The most basal
Paul S. Murray, Ronen Zaidel-Bar
doaj   +1 more source

Active wetting of epithelial tissues

, 2019
Development, regeneration and cancer involve drastic transitions in tissue morphology. In analogy with the behavior of inert fluids, some of these transitions have been interpreted as wetting transitions.
A Ravasio, AF Mertz, AF Mertz, AG Clark, AMJ Edwards, AR Harris, B Smeets, B Wallmeyer, C Blanch-Mercader, C Blanch-Mercader, C Cortina, Carles Blanch-Mercader, Carlos Pérez-González, D Bonn, D Gonzalez-Rodriguez, D Oriola, D Sarrió, DK Vig, DT Tambe, DT Tambe, E Bazellières, Elsa Bazellieres, F Jülicher, G Beaune, G Beaune, H Morita, I Muhamed, I Rodriguez-Hernandez, J Notbohm, J Paredes, J Prost, Jaume Casademunt, JL Ouderkirk, K Kruse, KA Paschos, L Casares, M Behrndt, M Deforet, Manuel Gómez-González, MC Marchetti, MH Köpf, O Chepizhko, P Campinho, P Friedl, P Gennes de, P Lee, P Lee, P Lu, PL Ryan, Ricard Alert, S Banerjee, S Douezan, S Douezan, S Douezan, S Garcia, S Kaliman, S Yabunaka, T Lecuit, TB Saw, Tomasz Kolodziej, TV Stirbat, US Schwarz, X Serra-Picamal, X Trepat, Xavier Trepat   +64 more
core   +3 more sources

Functions of p120ctn in development and disease [PDF]

, 2012
p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim, van Hengel, Jolanda, Van Roy, Frans   +2 more
core   +1 more source

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Peptide Bbeta(15-42) preserves endothelial barrier function in shock [PDF]

, 2009
Loss of vascular barrier function causes leak of fluid and proteins into tissues, extensive leak leads to shock and death. Barriers are largely formed by endothelial cell-cell contacts built up by VE-cadherin and are under the control of RhoGTPases. Here
Atrasheuskaya, Alena, Bukin, Eugenij, Friedl, Peter, Gröger, Marion, Hofer-Warbinek, Renate, Ignatyev, George, Knapp, Sylvia, Matt, Ulrich, Pasteiner, Waltraud, Petzelbauer, Peter, Reingruber, Sonja, Zacharowski, Kai, Zinkl, Daniela   +12 more
core  

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development

eLife, 2020
An extracellular matrix of Fibronectin adheres the neural tube to the two flanking columns of paraxial mesoderm and is required for normal vertebrate development.
Emilie Guillon, Dipjyoti Das, Dörthe Jülich, Abdel-Rahman Hassan, Hannah Geller, Scott Holley   +5 more
doaj   +1 more source

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]

, 2014
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N, Lazarevich NL, Michelotti GA, Omenetti A, Spagnoli FM, Treyer A, Valdes F   +6 more
core   +3 more sources