Results 251 to 260 of about 321,674 (333)

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity. [PDF]

iScience
Wang DM, Yang J, Ansari MO, Arbieva Z, Maienschein-Cline M, Natarajan V, Malik AB, Tiruppathi C.   +7 more
europepmc   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Paths to stability - actin regulation of adherens junction mechanics. [PDF]

J Cell Sci
James J, Winn LBA, Mottram-Epson P, Köster D.   +3 more
europepmc   +1 more source

CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response

Advanced Science, EarlyView.
Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen, Yinde Huang, Juntong Wu, Ziying Yi, Yao Li, Zeyu Yang, Fan Zhang, Chong Li   +7 more
wiley   +1 more source

Salvianolic acid B inhibits the proliferation and metastasis of A549 lung cancer cells via miR-23a/PTEN/AKT pathway. [PDF]

Sci Rep
Yang Y, Huang L, Dai L, Zhou X, Qian B.
europepmc   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

HSP90AA1 restrains clear cell renal cell carcinoma progression by promoting CADM1 expression and suppressing the PI3K-AKT pathway through interaction with FBXO7. [PDF]

Cell Death Discov
Yang W, Li Y, Li Z, Jiang C, Deng X, Peng D.   +5 more
europepmc   +1 more source

Cadherin-11 [PDF]

, 2020
openaire   +1 more source

Cadherin‐26 Facilitates Transepithelial Migration of Eosinophils in Eosinophilic Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by persistent sinonasal inflammation and marked eosinophilic infiltration. Although the relationship between eosinophils and NP formation has been extensively studied, the mechanisms governing eosinophil transepithelial migration into the nasal mucosa ...
Yeong‐In Jo, Jee Won Moon, Joo‐Hoo Park, Hwa Eun Yang, Subin Cho, Hyeongguk Son, Hyun‐Woo Yang, Il‐Ho Park   +7 more
wiley   +1 more source