Results 261 to 270 of about 284,314 (352)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Soluble E-Cadherin as a New Prognostic Biomarker Able to Predict Survival in Newly Diagnosed Diffuse Large B-Cell Lymphoma. [PDF]

Biomolecules
da Silva PCRM, de Almeida ICTDS, Dos Santos JG, Otuyama LJ, Reichert CO, Culler HF, de Aquino NC, França LS, da Siqueira SAC, Costa RO, Rocha V, Bydlowski SP, Levy D, Pereira J, Lage LAPC.   +14 more
europepmc   +1 more source

Clinical Validation of a QSP Model for ISB 2001, a Trispecific T Cell Engager to Support Optimal FIH Study Design in RRMM Patients

Clinical Pharmacology &Therapeutics, EarlyView.
ISB 2001 is a trispecific antibody that binds to two tumor‐associated antigens (TAA), CD38 and BCMA, and crosslinks to CD3 on T cells resulting in T cell‐mediated cytotoxicity of tumor cells expressing these TAAs. ISB 2001 is currently being tested in relapsed and/or refractory multiple myeloma (RRMM) patients in the first‐in‐human (FIH) TRIgnite‐1 ...
Vinu Chandralayam Ayyappa Menon, Tomomi Matsuura, Beata Holkova, Girish S. Gudi, Adam Drake, Maria Pihlgren, Piet H. van der Graaf, Sunitha GN, Andrew Garton, Mario Perro, Cyril Konto, Lida Pacaud   +11 more
wiley   +1 more source

Investigation of angiogenesis and epithelial-mesenchymal transition markers (CD31, VEGF, and E-Cadherin) in prostatic cancer patients: a multi-omics study. [PDF]

World J Surg Oncol
Shahshenas S, Jalali Nadoushan M, Yarmohammadi H, Soltanipur M.   +3 more
europepmc   +1 more source

Quantitative Detection of Entotic Cell‐In‐Cell Structures Using Deformable Segmentation and Deep Learning

Cytometry Part A, EarlyView.
ABSTRACT Cell‐in‐cell (CIC) structures are among the most intriguing cellular phenomena occasionally observed in human cancer specimens. Once regarded as incidental findings, accumulating evidence has linked specific CIC subtypes, particularly entosis, to tumor progression and patient prognosis.
Maria V. Leyba‐Mesa, Mikołaj Biegański, Elijah Ray, Izabela Młynarczuk‐Bialy, Buket D. Barkana   +4 more
wiley   +1 more source

Isatin-mediated inhibition of the PI3K/AKT/EMT signaling axis confers antitumor efficacy in Ehrlich solid carcinoma-bearing mice. [PDF]

BMC Cancer
Effat H, Ibrahim MA, Abohashem RS, Attia YM, Abdelwahed FM.   +4 more
europepmc   +1 more source

Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

Developmental Dynamics, EarlyView.
Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu, Katja R. MacCharles, Kenneth Kin Lam Wong, Joy M. Richman, Esther M. Verheyen   +4 more
wiley   +1 more source

The role of naturally-occurring canine tumors in translating conserved consequences of epithelial-mesenchymal plasticity to human cancers. [PDF]

Front Vet Sci
Bakhle KM, Dongre A.
europepmc   +1 more source

Biophysical processes of morphogenesis in lizard lungs

Developmental Dynamics, EarlyView.
Abstract Background The lungs of squamate reptiles (lizards and snakes) are highly diverse, exhibiting single chambers, multiple chambers, transitional forms with two to three chambers, along with a suite of other anatomical features, including finger‐like epithelial projections into the body cavity known as diverticulae.
Kaleb Hill, Aaron H. Griffing, Michael A. Palmer, Bezia Lemma, Aria S. Lupo, Tony Gamble, Natalia A. Shylo, Andrej Košmrlj, Paul A. Trainor, Celeste M. Nelson   +9 more
wiley   +1 more source

MEF2A nuclear translocation mediated by ROCK phosphorylation promotes EZH2 expression and peritoneal fibrosis. [PDF]

Ren Fail
Chen D, Sun Z, Xu Y, Wang Q.
europepmc   +1 more source