Results 31 to 40 of about 524,600 (358)

Dynamics of cadmium acclumulation in the internal organs of rats after exposure to cadmium chloride and cadmium sulphide nanopartiles of various sizes.

Medičnì Perspektivi, 2017
The article presents the results of study of cadmium accumulation in the internal organs of Wistar rats after prolonged intraperitoneal administration of cadmium chloride and cadmium sulphide nanoparticles of 4-6 nm and 9-11 nm in size in a dose of 0.08 ...
O. L. Apykhtina, K. P. Kozlov
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Risk assessment on the dietary exposure of cadmium in Guangxi residents

Zhongguo shipin weisheng zazhi, 2021
Objective To analyze the cadmium level in main food, and assess the risk of dietary exposure of residents in Guangxi. Methods The cadmium content in 39 kinds of food was analyzed statistically from 2013 to 2018.
Yuyan JIANG, Ning MA, Haoyang MENG, Mengmeng SHI, Peng ZHAO   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Cadmium Tolerance and Detoxification Mechanisms of Lentinula edodes: Physiology, Subcellular Distribution, and Chemical Forms

Microorganisms
Lentinula edodes has a strong cadmium-enrichment ability, posing a potential threat to human health. However, the cadmium tolerance and detoxification mechanisms of Lentinula edodes are not understood.
Gaigai Chen, Bowen Han, Wene Nan, Xiaobo Dong   +3 more
doaj   +1 more source

The Effect of Exogenous Cadmium and Zinc Applications on Cadmium, Zinc and Essential Mineral Bioaccessibility in Three Lines of Rice That Differ in Grain Cadmium Accumulation

Foods, 2023
Millions of people around the world rely on rice (Oryza sativa) for a significant portion of daily calories, but rice is a relatively poor source of essential micronutrients like iron and zinc.
Michael Tavarez, Michael A. Grusak, Renuka P. Sankaran   +2 more
doaj   +1 more source

The effect of dietary cadmium on kidney function in cats : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Animal Science at Massey University, Palmerston North, New Zealand [PDF]

, 2017
Due to the requirement for meat in feline diets, this study aimed to investigate the potential effects on kidney function in cats of cadmium accumulation in meat products due to pasture management practices.
Anderson, Jeanette M J
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The association between serum cadmium and diabetes in the general population: A cross-sectional study from NHANES (1999–2020)

Frontiers in Nutrition, 2022
BackgroundAssociations between serum cadmium and diabetes had been reported in previous studies, however there was still considerable controversy regarding associations.
Rongpeng Gong, Xiaolu Pu, Zhenqian Cheng, Jie Ding, Zhenghao Chen, Yongjun Wang, Yongjun Wang   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source