Results 141 to 150 of about 36,225 (301)
Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization
iMetaOmics, EarlyView.Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao +10 more
wiley +1 more source
Lactobacillus derived small RNAs protect against Klebsiella pneumoniae infection
iMeta, EarlyView.This study reveals that plant‐derived natural products confer protection against carbapenem‐resistant Klebsiella pneumoniae (CRKP) infection via remodeling the gut microbiota, with Lactobacillus identified as the core beneficial genus. Mechanistically, Lactobacillus murinus (L.
Tingting Xu +5 more
wiley +1 more source
Caecal duplication in a neonate causing intestinal obstruction
Nigerian Journal of PaediatricsIntestinal duplication is one of the rare congenital abnormalities encountered. Duplications found on the small intestine are more commonly encountered in clinical practice than the large intestine and majority of these occurs in the ileum. We present a
Mava Y +5 more
doaj
iNew Medicine, EarlyView.A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Objective Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted ...
Shao‐qi Wu +11 more
wiley +1 more source
Metrnl: A Novel Therapeutic Target in Atherosclerosis
iNew Medicine, EarlyView.ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley +1 more source
Interdisciplinary Medicine, EarlyView.Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li +15 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.Schematic depicting a gut‐brain pathway that exacerbates CST injury after ICH. Gut Microbiota Dysbiosis‐Mediated Gut NLRP3 Inflammasome Activation Exacerbates Corticospinal Tract Injury After Intracerebral Hemorrhage. Abstract Intracerebral hemorrhage (ICH) causes severe neurological deficits largely attributable to corticospinal tract (CST) injury ...
Meiqin Zeng +11 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley +1 more source