Results 181 to 190 of about 148,951 (345)
British Journal of Pharmacology, EarlyView.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
wiley +1 more source
Beyond synapses: cytoplasmic connections in brain function and evolution
Biological Reviews, EarlyView.ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley +1 more source
The pace and shape of ant ageing
Biological Reviews, EarlyView.ABSTRACT Ants have been proposed as good models to study ageing and the effects of extrinsic mortality because of their long lifespans and plasticity of ageing within species. We discuss how age‐dependent extrinsic mortality might influence queen lifespan, and how the effect of age‐independent extrinsic mortality needs further study, accounting for ...
Luisa M. Jaimes‐Nino, Jan Oettler
wiley +1 more source
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. [PDF]
, 1994 Sharad Kumar +4 more
openalex +1 more source
Plasticity in climate change responses
Biological Reviews, EarlyView.ABSTRACT Recent research has shown that climate change can both induce and modulate the expression of plastic traits but our understanding of the role of phenotypic plasticity as an adaptive response to climate change is limited. In this review, we dissect the mechanisms and impact of phenotypic plasticity as a response to accumulating climatic ...
Angelika Stollewerk +18 more
wiley +1 more source
Toxicity of glyphosate accelerates neurodegeneration in <i>Caenorhabditis elegans</i> model of Alzheimer's disease. [PDF]
Front ToxicolRani N, Alam MM, Parvez S.
europepmc +1 more source
Cell Proliferation, EarlyView.KB2764 interacted with alpha‐enolase (ENO1) and pyruvate kinase M (PKM), ultimately leading to PKM phosphorylation of ENO1. KB2764 consequently increased mitochondrial ATP production and decreased glycolysis dependence. Furthermore, the action of KB2764 extends its application to extend the lifespan of Caenorhabditis elegans.
Yun Haeng Lee +13 more
wiley +1 more source
Nematode mind: exploring the role of the RNA interference pathway in learning, memory and beyond. [PDF]
Philos Trans R Soc Lond B Biol SciZwoinska MK +4 more
europepmc +1 more source
Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44
The FEBS Journal, EarlyView.Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser +9 more
wiley +1 more source