Results 211 to 220 of about 121,076 (308)

Epigenetic constraints and enhancer innovation link neuronal plasticity to evolutionary adaptation. [PDF]

open access: yesProc Natl Acad Sci U S A
Millán-Trejo A   +7 more
europepmc   +1 more source

Deciphering the Function and Structure of PA1216 as an S‐Adenosyl‐l‐Methionine Binding Protein Using Differential Scanning Fluorimetry and Circular Dichroism

open access: yesProtein Science, Volume 35, Issue 8, August 2026.
Abstract Microbes produce bioactive secondary metabolites as toxins, pigments, or virulence factors. These specialized compounds are produced by nonribosomal peptide synthetases (NRPS), polyketide synthases (PKS), or hybrid NRPS/PKS pathways. The genes encoding NRPS and PKS reside in biosynthetic gene clusters (BGCs), some of which have no identified ...
Amaan M. Fruitwala   +4 more
wiley   +1 more source

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept

open access: yesEnvironmental Toxicology, Volume 41, Issue 8, Page 507-522, August 2026.
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos   +3 more
wiley   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 15, Page 4399-4415, August 2026.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci   +15 more
wiley   +1 more source

Making fish oils in plants: from alpha to omega

open access: yesNew Phytologist, Volume 251, Issue 3, Page 1013-1018, August 2026.
Schematic representation of the biosynthetic pathway for the synthesis of omega‐3 long‐chain polyunsaturated fatty acids. The sequential transgene‐encoded activities required to convert endogenous fatty acids to the longer chain polyunsaturated forms of eicosapentaenoic acid and docosahexaenoic acid are shown in red.
Johnathan A. Napier
wiley   +1 more source

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