Results 71 to 80 of about 148,951 (345)
Advanced Science, EarlyView.Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang +14 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2022 The nematode Caenorhabditis briggsaeCaenorhabditis elegansC. briggsaeC. briggsaetransC. briggsaeC. briggsaeC. elegansC. elegansC.
Nikita Jhaveri +5 more
doaj +1 more source
Advanced Science, EarlyView.Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou +16 more
wiley +1 more source
The Caenorhabditis elegans Transgenic Toolbox
Genetics, 2019 The power of any genetic model organism is derived, in part, from the ease with which gene expression can be manipulated. The short generation time and invariant developmental lineage have made Caenorhabditis elegans very useful for understanding, e.g ...
Jeremy Nance, Christian Frøkjær-Jensen
semanticscholar +1 more source
The natural history of Caenorhabditis elegans [PDF]
Current Biology, 2010 SummaryIn the laboratory, the nematode Caenorhabditis elegans lives on the surface of nutrient agar in Petri dishes, feeding on a lawn of the uracil auxotroph strain OP50, an Escherichia coli mutant strain. This sentence sums up the fundamentals of C. elegans ecology, as most of us know it. While over 15,000 articles on diverse biological aspects of C.
Félix, Marie-Anne, Braendle, Christian
openaire +3 more sources
Advanced Science, EarlyView.An integral functional axis through which GPN and functional metabolites of Alistipes senegalensis can hydrolyze tryptophan into indoles. Furthermore, the Alistipes senegalensis‐indole‐AhR pathway is found to be associated with increased expression of tight junction‐associated proteins and activation of gut stem cells.
Dandan Wang +10 more
wiley +1 more source
Cerium oxide nanoparticle aggregates affect stress response and function in
SAGE Open Medicine, 2015 Objective: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of nanoparticles on the environmental and human health.
Steven Rogers +6 more
doaj +1 more source
The native microbiome of the nematode Caenorhabditis elegans: gateway to a new host-microbiome model
BMC Biology, 2016 Host-microbe associations underlie many key processes of host development, immunity, and life history. Yet, none of the current research on the central model species Caenorhabditis elegans considers the worm’s natural microbiome.
P. Dirksen +11 more
semanticscholar +1 more source
Post‐Translational Modifications in Cilia and Ciliopathies
Advanced Science, EarlyView.This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source
Angewandte Chemie, EarlyView.Utilizing quadrature phase modulation, the phase‐shifted polarization SRS (QP2‐SRS) microscope enables simultaneous measurement of the ρ‐related χ1111(3)$\chi _{1111}^{( 3 )}$ and χ1221(3)$\chi _{1221}^{( 3 )}$ components. In cholesterol molecular measurements, QP2‐SRS leverages the structural differences between cholesterol and other biomolecules to ...
Yongqing Zhang +7 more
wiley +2 more sources