Results 101 to 110 of about 279,189 (378)
DANSing with Caenorhabditis elegans [PDF]
Proceedings of the National Academy of Sciences, 2009 The emergence of natural product research over the past decades has largely been driven by the discovery of biologically active metabolites for drug discovery programs (1). A broad array of organisms, including bacteria and fungi, and plants and animals have provided such important antibiotics as erythromycin, tetracycline and the penicillins ...
David H. Sherman, Patrick J. Hu
openaire +3 more sources
Post‐Translational Modifications in Cilia and Ciliopathies
Advanced Science, EarlyView.This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source
Disease Models & Mechanisms, 2020 First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Éva Saskői is first author on ‘The SDHB Arg230His
doaj +1 more source
Nature Communications, 2020 Caenorhabditis elegans exhibits multigenerational adaptation to bacterial infection but the mechanisms remain unclear. Here, the authors show that C.
Nicholas O. Burton +6 more
doaj +1 more source
Unraveling the mechanisms of synapse formation and axon regeneration: the awesome power of C. elegans genetics. [PDF]
, 2015 Since Caenorhabditis elegans was chosen as a model organism by Sydney Brenner in 1960's, genetic studies in this organism have been instrumental in discovering the function of genes and in deciphering molecular signaling network.
Jin, YiShi
core +3 more sources
Advanced Science, EarlyView.Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter‐tissue communications of fatty acids between the liver and other tissues is developed. Moreover, the approach is extended to aging condition and a system‐wide decline of fatty acid synthesis in peripheral ...
Beizi Xing +4 more
wiley +1 more source
Caenorhabditis elegans and probiotics interactions from a prolongevity perspective [PDF]
, 2019 Probiotics exert beneficial effects on host health through different mechanisms of action, such as production of antimicrobial substances, competition with pathogens, enhancement of host mucosal barrier integrity and immunomodulation.
Barbara Guantario +5 more
core +1 more source
Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT
Advanced Science, EarlyView.Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai +13 more
wiley +1 more source
FIONA on Caenorhabditis elegans [PDF]
Biochemistry, 2009 Despite much work, subcellular neurons of Caenorhabditis elegans have not been studied at nanometer resolution with millisecond time resolution. Nor has there been an effective way to immobilize C. elegans. Here we show that, without using anesthetic or paralyzing agents, fluorescence imaging with one-nanometer accuracy (FIONA) can be successfully ...
Paul R. Selvin +2 more
openaire +3 more sources
Structural Basis of GABAB Receptor Activation during Evolution
Advanced Science, EarlyView.This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou +14 more
wiley +1 more source