Results 131 to 140 of about 279,189 (378)

Multigenome DNA sequence conservation identifies Hox cis-regulatory elements [PDF]

, 2008
To learn how well ungapped sequence comparisons of multiple species can predict cis-regulatory elements in Caenorhabditis elegans, we made such predictions across the large, complex ceh-13/lin-39 locus and tested them transgenically. We also examined how
De Buysscher, Tristan, DeModena, John A., Kuntz, Steven G., Schwarz, Erich M., Shizuya, Hiroaki, Sternberg, Paul W., Trout, Diane, Wold, Barbara J.   +7 more
core   +3 more sources

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, EarlyView., 2023
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Biosynthesis and enzymology of the Caenorhabditis elegans cuticle: identification and characterization of a novel serine protease inhibitor. [PDF]

, 2006
The nematode Caenorhabditis elegans represents an excellent model in which to examine nematode gene expression and function. A completed genome, straightforward transgenesis, available mutants and practical genome-wide RNAi approaches provide an ...
Andrew J. Birnie, Antony P. Page, Brenner, Brooks, Canty, Chu, Davis, Edens, Eschenlauer, Frand, Friedman, Gillian McCormack, Hawdon, Hill, Johnstone, Kamath, Kamath, Kramerova, Kramerova, Kress, Lustigman, Milstone, Myllyharju, Myllyharju, Novelli, Page, Page, Page, Page, Page, Pappano, Peters, Poole, Roberts, Sapio, Simmer, Singh, Sulston, Thacker, Thacker, Thein, Winter, Yang   +42 more
core   +1 more source

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

eLife, 2017
Autophagy has been linked to longevity in many species, but the underlying mechanisms are unclear. Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we quantified autophagic vesicles and performed autophagic flux assays in multiple tissues ...
Jessica T. Chang, Caroline Kumsta, Andrew B. Hellman, Linnea M Adams, M. Hansen   +4 more
semanticscholar   +1 more source

Untwisting the Caenorhabditis elegans embryo

eLife, 2015
The nematode Caenorhabditis elegans possesses a simple embryonic nervous system with few enough neurons that the growth of each cell could be followed to provide a systems-level view of development. However, studies of single cell development have largely been conducted in fixed or pre-twitching live embryos, because of technical difficulties ...
Daniel A. Colón-Ramos, William A. Mohler, Huafeng Liu, Evan McCreedy, Yicong Wu, Zhirong Bao, Abhishek Kumar, Abhishek Kumar, Nicole Tashakkori, Peter Winter, Javier Marquina-Solis, Matthew McAuliffe, Ismar Kovacevic, Alexandra Bokinsky, Min Guo, Min Guo, Hari Shroff, Anthony Santella, Ryan Christensen   +18 more
openaire   +4 more sources

The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes [PDF]

, 2010
The cuticle of parasitic nematodes performs many critical functions and is essential for proper development and for protection from the host immune response.
Antony P. Page, Bernard, Blaxter, Chu, Cook, Fessler, Ford, Frand, Ghedin, Gillian McCormack, Gillian Stepek, Hawdon, Johnstone, Johnstone, Kingston, Kingston, Kramerova, Kramerova, Kress, Mieszczanek, Milstone, Nagano, Novelli, Novelli, Paesen, Page, Page, Poole, Priess, Redmond, Rhoads, Sasaki, Scott, Shamansky, Skuce, Stanssens, Studier, Thacker, Thacker, Thacker, Thacker, Thein, Wells, Winter   +43 more
core   +1 more source

Nucleologenesis in the Caenorhabditis elegans Embryo

PLoS ONE, 2012
In the Caenorhabditis elegans nematode, the oocyte nucleolus disappears prior to fertilization. We have now investigated the re-formation of the nucleolus in the early embryo of this model organism by immunostaining for fibrillarin and DAO-5, a putative NOLC1/Nopp140 homolog involved in ribosome assembly.
Christian Lanctôt, Adriána Gombitová, Dušan Cmarko, Darina Korčeková, Ivan Raška   +4 more
openaire   +5 more sources

A new defense in the battle of the sexes

eLife, 2019
Young Caenorhabditis elegans hermaphrodites use their own sperm to protect against the negative consequences of mating.
George L Sutphin
doaj   +1 more source

A transcriptomic snapshot of early molecular communication between Pasteuria penetrans and Meloidogyne incognita [PDF]

, 2018
© The Author(s). 2018Background: Southern root-knot nematode Meloidogyne incognita (Kofoid and White, 1919), Chitwood, 1949 is a key pest of agricultural crops.
A Clark, AF Bird, AG Whitehead, AJ van Rossum, AN Nathoo, AR Hipkiss, AR Quinlan, B Boettner, B Ketterer, B Li, B Mannervik, B Raymond, C The, CA Perrett, CA Reinitz, CD Sifri, D Wong, DL McEwan, E Moreno-Arriola, E Peter, EE Penhoet, EL Pavlova, ES Kim, FA Partridge, FX Yu, G Simons, H Li, HR Nicholas, I Mohr, IK Vagelas, IR Cohen, Irene Bricchi, J Heino, J Papadopoulou, J Tang, J. P. Yan, JA Melo, JF Preston, K Hesp, K Kim, K. G. DAVIES, Keith G. Davies, KG Bankar, KG Davies, KG Davies, KG Davies, KG Davies, KH Nomura, KJ Livak, L Charles, L Lambrechts, L Lambrechts, LB Cohen, LE Waggoner, M Cohen, M Klass, MA Bakowski, MA Miller, ME Feder, MG Grabherr, MJ Gravato-Nobre, MR Calgaro, MS Gami, MS Kwa, N Borghi, N Kogata, N Lane, N Schormann, N Tavernarakis, N Tavernarakis, N Vibanco-P’erez, O Silva-García, P Abad, P. B. Szecsi, PE Kuwabara, PE Urwin, PK Papolu, PM Brophy, PM Brophy, PM Guimaraes, R Erion, R Roberts, RK Patel, RM Sayre, Rohit N. Shukla, S Anders, S Choi, S Das, S Echevarria-Zomeno, S Mahajan-Miklos, SC Johnson, SC Zevian, SE Chang, SF Altschul, SHE Kaufmann, SJ McTaggart, SM Barribeau, TE Hewlett, TJ Krieger, TL Dunbar, TM Kubiak, TM Roberts, TM Shinnick, U Rao, Uma Rao, V Giguere, V Phani, V Phani, V Phani, Victor Phani, Victor Phani, Vishal S. Somvanshi, X Chen, X Zou, Y Gonskikh, Y Moriya, Y Spiegel, Y Yarden, Y Zhang   +118 more
core   +2 more sources