Results 171 to 180 of about 193,403 (293)

Dietary cinnamon promotes longevity and extends healthspan via mTORC1 and autophagy signaling

Aging Cell, Volume 24, Issue 4, April 2025.
Dietary cinnamon extends lifespan, enhances stress resistance, and ameliorates β‐Amyloid toxicity in C. elegans. Its effects are mediated by mTORC1 and autophagy signaling. Interestingly, cinnamon mimics the effect of dietary restriction without altering food intake.
Yuling Guo, Qing Zhang, Bi Zhang, Tong Pan, Elizabeth A. Ronan, Anthony Huffman, Yongqun He, Ken Inoki, Jianfeng Liu, X.Z. Shawn Xu   +9 more
wiley   +1 more source

ANALYSIS OF GENETIC MOSAICS OF THE NEMATODE CAENORHABDITIS ELEGANS [PDF]

, 1984
Robert K Herman
openalex   +1 more source

Epidermal Collagen Reduction Drives Selective Aspects of Aging in Sensory Neurons

Aging Cell, Volume 24, Issue 4, April 2025.
Reduced collagen on the epidermal apical surface drives selective aging in sensory neurons of Caenorhabditis elegans, leading to excessive dendritic branching and related functional deficits. An immunoglobulin superfamily protein in interneurons acts upstream of collagen genes to maintain dendritic homeostasis during aging, with a downstream ...
Meera M. Krishna, Swapnil G. Waghmare, Ariel L. Franitza, Emily C. Maccoux, Lezi E   +4 more
wiley   +1 more source

Monoclonal antibodies that recognize a polypeptide antigenic determinant shared by multiple Caenorhabditis elegans sperm-specific proteins. [PDF]

, 1986
Samuel Ward, Thomas M. Roberts, Susan Strome, Fredrick M. Pavalko, Eileen Hogan   +4 more
openalex   +1 more source

Optimising Age‐Specific Insulin Signalling to Slow Down Reproductive Ageing Increases Fitness in Different Nutritional Environments

Aging Cell, Volume 24, Issue 5, May 2025.
We found that reducing insulin signalling in adult worms slows down their reproductive ageing and extends their lifespan without negative side effects. Moreover, combining it with IF further enhances these benefits. These interventions likely work by regulating genes linked to biosynthesis and immunity, showing how optimising gene expression can delay ...
Zahida Sultanova, Aykut Shen, Katarzyna Hencel, Hanne Carlsson, Zoe Crighton, Daniel Clifton, Alper Akay, Alexei A. Maklakov   +7 more
wiley   +1 more source

Recombination between small X chromosome duplications and the X chromosome in Caenorhabditis elegans. [PDF]

, 1989
Robert K Herman, Claire K Kari
openalex   +1 more source

Genetic and Pharmacological Inhibition of Metabotropic Glutamate Receptor Signalling Extends Lifespan in Drosophila

Aging Cell, Volume 24, Issue 5, May 2025.
We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan, Abigail Otchere, Mihails Laskovs, Irene Papatheodorou, Cathy Slack   +4 more
wiley   +1 more source

Negative Effect of Gst‐35 on the Health Span of Caenorhabditis elegans Through Lysosomal Dysfunction via the Pmk‐1 and Skr Genes

Aging Cell, EarlyView.
The overexpression of gst‐35, the mammalian orthologous genes GSTA1, GSTA2, and GSTA3, induces lysosomal dysfunction through the genes pmk‐1 and skr in C. elegans. This overexpression not only promotes an in vivo inflammatory response and accumulation of reactive oxygen species but also significantly shortens the nematode lifespan; inhibits its ...
Yehui Gao, Xinyun Zhang, Congmin Wei, Hongru Lin, Mengchen Wu, Botian Ma, Jinyun Jiang, Shan Li, Hongbing Wang   +8 more
wiley   +1 more source

Isolatio and characterization of metallothionein from nematode(Caenorhabditis elegans)

, 1986
KOHJI MARUYAMA, Ritsuko Hori, Tsutomu Nishihara, Masaomi Kondo   +3 more
openalex   +2 more sources

Occurrence of muscarinic acetylcholine receptors in wild type and cholinergic mutants of Caenorhabditis elegans [PDF]

, 1983
JG Culotti, WL Klein
openalex   +1 more source