Results 201 to 210 of about 279,189 (378)

Targeting the SOD1‒MMP‐2‒COLXVII axis: A therapeutic strategy for age‐related tissue degeneration

VIEW, EarlyView.
Our work identifies a novel role for MMP‐2 in driving senescence‐associated skin and muscle degeneration through ECM degradation. We demonstrate that inhibiting MMP‐2 activity restores tissue integrity by preserving COLXVII, revealing a new therapeutic pathway for combating oxidative stress‐induced tissue aging. Using both mammalian and nematode models,
Juewon Kim, Shuichi Shibuya, Masahiko Terajima, Yuki Taga, Kazunori Mizuno, Eunji Lee, Seokwon Han, Woo‐Young Seo, Takahiko Shimizu   +8 more
wiley   +1 more source

Recombination between small X chromosome duplications and the X chromosome in Caenorhabditis elegans. [PDF]

, 1989
Robert K Herman, Claire K Kari
openalex   +1 more source

Seeing the Unseen: Structured Illumination Microscopy for Organelles Dynamics

VIEW, EarlyView.
Abstract Super‐resolution microscopy (SRM) has revolutionized the field of biological imaging by surpassing the diffraction limit of light and rendering us the ability to visualize cellular structures and processes at unprecedented resolution. This powerful technique enables the observation of nanoscale details, thereby providing insights into ...
Adrian Tan, Changcheng Lai, Zhiqi Tian, Aditya Yadav, Jiajie Diao   +4 more
wiley   +1 more source

Insertion and excision of Caenorhabditis elegans transposable element Tc1. [PDF]

, 1988
David Eide, Philip Anderson
openalex   +1 more source

Plastamination: A Rising Concern for Parkinson's Disease

Movement Disorders, EarlyView.
Roberto Erro, Cristiano Sorrentino, Paolo Barone   +2 more
wiley   +1 more source

Host avoidance and resistance vary independently and are specific to parasite genotype

Journal of Animal Ecology, EarlyView.
Hosts may defend themselves against parasites by avoiding contact or by mounting a resistance defense after contact. This study shows that avoidance and resistance are highly specific across nematode host and bacterial parasite strain pairings, but avoidance and resistance do not covary across host strains.
Caroline R. Amoroso, Adianna Lockwood‐Shabat, Andreas Kamali, Amanda K. Gibson   +3 more
wiley   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, EarlyView.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source

Occurrence of muscarinic acetylcholine receptors in wild type and cholinergic mutants of Caenorhabditis elegans [PDF]

, 1983
JG Culotti, WL Klein
openalex   +1 more source

Metformin and Dietary Restriction Counteract Aging via Reducing m6A–Dependent Stabilization of Methionine Synthase mRNA in Brachionus asplanchnoidis (Rotifera)

Aging Cell, EarlyView.
Metformin and dietary restriction modulate m6A to extend lifespan of rotifer, highlighting MTR as a central regulator of aging through methionine metabolism. ABSTRACT Metformin, a medication primarily used to treat diabetes, has gained attentions for its potential antiaging properties.
Yu Zhang, Xiaojie Liu, Hairong Lian, Yanchao Chai, Yang Zhou, Dongqi Kan, Jilong Ren, Cui Han, Jiaxin Yang   +8 more
wiley   +1 more source

ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds

Aging Cell, EarlyView.
ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan, Hongxia Cai, Fang Ye, Wentao Xu, Zhihang Huang, Jingyuan Zhu, Yiwen Gong, Yutong Li, Anastasia Ngozi Ezemaduka, Shan Gao, Shunqi Liu, Guojun Li, Hao Li, Jing Yang, Junyu Ning, Bo Xian   +15 more
wiley   +1 more source