Results 211 to 220 of about 279,189 (378)

Multiple forms of histone H2B from the nematode Caenorhabditis elegans [PDF]

open access: green, 1986
Jacques R. Vanfleteren   +3 more
openalex   +1 more source

Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis

open access: yesAging Cell, EarlyView.
The authors provide evidence that, together with Dietary Restriction, Rapamcyin and not Metformin, provides a significant lifespan extension in vertebrates. ABSTRACT Dietary restriction (DR) robustly increases lifespan across taxa. However, in humans, long‐term DR is difficult to maintain, leading to the search for compounds that regulate metabolism ...
Edward R. Ivimey‐Cook   +2 more
wiley   +1 more source

Age-specific nuclear proteins in the nematode worm Caenorhabditis elegans [PDF]

open access: green, 1987
Lydie Meheus   +3 more
openalex   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

open access: yesBrain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li   +7 more
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

open access: yesBritish Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi   +10 more
wiley   +1 more source

Beyond synapses: cytoplasmic connections in brain function and evolution

open access: yesBiological Reviews, EarlyView.
ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley   +1 more source

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