Results 261 to 270 of about 118,692 (314)

Aging, Dauer, and Stature Phenotypes Are Conferred by Structure‐Directed Missense Mutations in the Endogenous AGE‐1/Phosphatidylinositol 3‐Kinase Catalytic Subunit

Aging Cell, Volume 25, Issue 6, June 2026.
Structure‐guided missense mutations in the C. elegans AGE‐1/PI3Kinase catalytic subunit and its LET‐60/Ras‐binding interface reveal separable signaling outputs from the Ras‐bound PI3K complex. Enhanced canonical catalytic activity, conferred by a gain‐of‐function mutation modeled on oncogenic human p110⍺ PI3K variants, promotes aging, reproductive ...
You Wu, Tam Duong, Neal R. Rasmussen, Kent L. Rossman, David J. Reiner   +4 more
wiley   +1 more source

Atypical Tetracyclines Promote Longevity and Ferroptotic Neuroprotection via Translation Attenuation

Aging Cell, Volume 25, Issue 6, June 2026.
Tetracyclines extend lifespan and protect neurons from ferroptosis by attenuating protein synthesis across multiple eukaryotic models through ISR‐dependent or ISR‐independent mechanisms, enabling classification based on their mode of action. ABSTRACT Reducing protein synthesis extends lifespan across taxa, but pharmacological strategies to safely ...
Khalyd J. Clay, Manuel Sanchez‐Alavez, Ian Newman, Na Na, Ana P. Verduzco Espinoza, Alan To, Shannon Saad, Hollis T. Cline, Michael Petrascheck   +8 more
wiley   +1 more source

The dopaminergic system of <i>Caenorhabditis elegans</i>. [PDF]

R Soc Open Sci
Muralidhara I, Hardege I.
europepmc   +1 more source

Kinesins in <i>Caenorhabditis elegans</i> neuronal morphogenesis. [PDF]

Open Biol
Niwa S, Chiba K.
europepmc   +1 more source

Intestinal and epidermal-specific analysis of ZIP-1 function and expression in <i>Caenorhabditis elegans</i>. [PDF]

MicroPubl Biol
Tirtorahardjo JA, Lažetić V, Troemel ER.   +2 more
europepmc   +1 more source

An investigation into the use of Caenorhabditis elegans as a model organism for nerve agent exposure research.

Neurotoxicology
Haszczyn J, Christopher Green A, Holden-Dye L, O'Connor V, Kearn J.   +4 more
europepmc   +1 more source

Antioxidant, antiaging and mitochondrial protective effects of JadeAging in Caenorhabditis elegans. [PDF]

Front Pharmacol
Lu B, Yin D, Zhang J, Wang Y, Wang X, Zou S, Li J.   +6 more
europepmc   +1 more source

Functional Characterization of Loss of <i>RNF43</i> Reveals Neuronal Defects in a <i>Caenorhabditis elegans</i> Model. [PDF]

Int J Mol Sci
Sonmez K, Güzel S, Kazan HH, Ekim B, Kaya C, Turkyilmaz Z, Karabulut R, Ergun MA.   +7 more
europepmc   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source