Results 51 to 60 of about 190,941 (272)

Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans. [PDF]

, 2019
Fam20C is a secreted protein kinase mutated in Raine syndrome, a human skeletal disorder. In vertebrates, bone and enamel proteins are major Fam20C substrates.
Adina Gerson-Gurwitz, Arribere, Arshad Desai, Bahl, Bando, Bies, Brown, Byerly, Cancino, Carolyn A. Worby, Carrascal, Cui, Dhanya Cheerambathur, Erin J. Cram, Fradin, Frøkjaer-Jensen, Gerald, Ghazarian, Gibson, Gorelik, Green, Ishikawa, Jack E. Dixon, Jeff Bouffard, Johnson, Kamath, Karen Oegema, Kian-Yong Lee, Kim, Kimble, Koike, Koob, Kovacevic, Köppen, Leiser, Leiser, Levin, Lindberg, Mann, Manning, Minko, Mody, Nakamura, Paschinger, Petrella, Pollak, Pollard, Pulvirenti, Raine, Reinhart, Renat Khaliullin, Rolls, Salvi, Sievers, Simpson, Sreelatha, Tagliabracci, Tagliabracci, Tagliabracci, Takeuchi, Tseng, Vogel, Wang, Ward, Wen, Wewer, Xiao, Yue, Zhang, Zhou, Zhou   +70 more
core   +3 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Wormwholes: A Commentary On K.F. Schaffer\u27s Genes, Behavior, And Developmental Emergentism [PDF]

, 1998
Although Caenorhabditis elegans was chosen and modified to be an organism that would facilitate a reductionist program for neurogenetics, recent research has provided evidence for properties that are emergent from the neurons. While neurogenetic advances
Gilbert, Scott F., Jorgensen, E. M.
core   +1 more source

Differences in collagen prolyl 4-hydroxylase assembly between two Caenorhabditis nematode species despite high amino acid sequence identity of the enzyme subunits [PDF]

, 2007
The collagen prolyl 4-hydroxylases (P4Hs) are essential for proper extracellular matrix formation in multicellular organisms. The vertebrate enzymes are α2β2 tetramers, in which the β subunits are identical to protein disulfide ...
Abrams, Alan D. Winter, Annunen, Annunen, Annunen, Antony P. Page, Bessereau, Crossen, D'Andrea, Friedman, Gillian McCormack, Helaakoski, Hieta, Hill, Johanna Myllyharju, John, Katriina Keskiaho, Kivirikko, Kivirikko, Kukkola, Lamberg, Liisa Kukkola, Marie-Anne Felix, Merriweather, Myllyharju, Myllyharju, Myllyharju, Myllyharju, Myllyharju, Myllyharju, Nissi, Page, Pekkala, Quevillon, Riihimaa, Stein, Sulston, Thein, Van den Diepstraten, Veijola, Veijola, Vuori, Williams, Winter, Winter   +44 more
core   +1 more source

Dielectrophoresis of Caenorhabditis elegans [PDF]

Lab on a Chip, 2011
We demonstrate for the first time the dielectrophoretic trapping and manipulation of a whole animal, the nematode Caenorhabditis elegans. We studied the effect of the electric field on the nematode as a function of field intensity and frequency. We identified a range of electric field intensities and frequencies that trap worms without apparent adverse
Han-Sheng, Chuang, David M, Raizen, Annesia, Lamb, Nooreen, Dabbish, Haim H, Bau   +4 more
openaire   +2 more sources

Packaging of Macroscopic Material Payloads: Needs, Challenges, Concepts, and Future Directions

Advanced Engineering Materials, EarlyView.
This review introduces a unified framework that decomposes any macroscopic packaging system into the payload, packaging material, and packaging strategy and combines them into a conceptual packaging equation: packaging strategy = payload + packaging material.
Venkata S. R. Jampani, Manos Anyfantakis
wiley   +1 more source

Progress in Caenorhabditis elegans as a Degenerative Disease Model for Molecular Pathways Studying

Shiyan dongwu yu bijiao yixue
With the acceleration of population aging in China, the number of patients with degenerative diseases has exceeded ten million, urgently requiring efficient mechanism research and drug screening systems.
SUN Han, GUO Peng, YU Xinhe, ZHANG Junqiao, YAO Ying, YANG Wen   +5 more
doaj   +1 more source

Biology and genome of a newly discovered sibling species of Caenorhabditis elegans

Nature Communications, 2018
Caenorhabditis nematodes are important model organisms. Here, the authors report the biology and genome of Caenorhabditis inopinata, a first sibling species of C. elegans, and develop genetic and molecular techniques for C. inopinata.
Natsumi Kanzaki, Isheng J. Tsai, Ryusei Tanaka, Vicky L. Hunt, Dang Liu, Kenji Tsuyama, Yasunobu Maeda, Satoshi Namai, Ryohei Kumagai, Alan Tracey, Nancy Holroyd, Stephen R. Doyle, Gavin C. Woodruff, Kazunori Murase, Hiromi Kitazume, Cynthia Chai, Allison Akagi, Oishika Panda, Huei-Mien Ke, Frank C. Schroeder, John Wang, Matthew Berriman, Paul W. Sternberg, Asako Sugimoto, Taisei Kikuchi   +24 more
doaj   +1 more source

The cuticle [PDF]

, 2007
The nematode cuticle is an extremely flexible and resilient exoskeleton that permits locomotion via attachment to muscle, confers environmental protection and allows growth by molting.
Johnstone, I. J., Page, A. P.
core   +1 more source

Immunometabolism in Caenorhabditis elegans

PLOS Pathogens, 2020
Here, we discuss 5 concepts that have emerged in studies of metabolic and immune interactions in C. elegans. The major emerging theme is that the immune response and the ability to survive pathogen infection is heavily influenced by pathogen-induced changes in host metabolism.
Sarah M. Anderson, Read Pukkila-Worley
openaire   +5 more sources