Results 71 to 80 of about 190,941 (272)

Prereplication complex proteins get caught moonlighting

PLoS Biology, 2022
In this issue of PLOS Biology, Lattmann and colleagues report a new function for proteins of the DNA prereplication complex promoting the anchor cell to invade through the basement membrane and initiate vulval development in Caenorhabditis elegans.
Hilary A. Coller
doaj  

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Measurement of Lysosomal Size and Lysosomal Marker Intensities in Adult Caenorhabditis elegans

Bio-Protocol, 2018
Assays have been developed to study trafficking in various tissues of Caenorhabditis elegans. Adult C. elegans intestinal cells are large and have extensive endocytic networks, thus making them a good system for deciphering the endocytic pathway using ...
Julie Huynh, Hope Dang, Hanna Fares
doaj   +1 more source

Caenorhabditis elegansExhibits Positive Gravitaxis [PDF]

BMC Biology, 2019
AbstractWhether or not the micro swimmerCaenorhabditis eleganssenses and respond to gravity is unknown. We find thatC. elegansaligns its swimming direction with that of the gravity vector (positive gravitaxis). When placed in an aqueous solution that is denser than the animals, they still orient downwards, indicating that non-uniform mass distribution ...
Wei-Long Chen, Hungtang Ko, Han-Sheng Chuang, David M. Raizen, Haim H. Bau   +4 more
openaire   +4 more sources

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor

Advanced Science, EarlyView.
Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang, Yixiang Deng, Nan Xia, Shuzo Sugita, Shangbang Gao   +4 more
wiley   +1 more source

Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. [PDF]

, 2012
BackgroundResponding to noxious stimuli by invoking an appropriate escape response is critical for survival of an organism. The sensations of small and large changes in temperature in most organisms have been studied separately in the context of ...
Ghosh, Rajarshi, Kruglyak, Leonid, Mohammadi, Aylia, Ryu, William S   +3 more
core   +3 more sources

Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming

Advanced Science, EarlyView.
Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong, Haiming Jing, Zinan Li, Wenjing Zhang, Nan Zhang, Yingqiu Xie, Shan Gao, Yuanyu Huang, Junyu Ning   +8 more
wiley   +1 more source

Lipidomic Analysis of Caenorhabditis elegans Embryos

Bio-Protocol, 2017
Metabolomic is an emerging field of system biology. Lipidomic, a branch of metabolomic, aims to characterize lipophilic metabolites in biological systems. Caenorhabditis elegans (C. elegans) is a genetically tractable and versatile animal model for novel
Hung-Chi Yang, Cheng-Yu Hung, Yi-Yun Pan, Szecheng Lo, Daniel Chiu   +4 more
doaj   +1 more source

A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains. [PDF]

, 2015
The genetic variants underlying complex traits are often elusive even in powerful model organisms such as Caenorhabditis elegans with controlled genetic backgrounds and environmental conditions.
Andersen, Erik C, Bloom, Joshua S, Crissman, Jonathan R, Gerke, Justin P, Ghosh, Rajarshi, Kruglyak, Leonid, Seidel, Hannah S, Shimko, Tyler C   +7 more
core   +2 more sources

Transcriptional adaptation in Caenorhabditis elegans

eLife, 2020
Transcriptional adaptation is a recently described phenomenon by which a mutation in one gene leads to the transcriptional modulation of related genes, termed adapting genes. At the molecular level, it has been proposed that the mutant mRNA, rather than the loss of protein function, activates this response.
Vahan Serobyan, Zacharias Kontarakis, Mohamed A El-Brolosy, Jordan M Welker, Oleg Tolstenkov, Amr M Saadeldein, Nicholas Retzer, Alexander Gottschalk, Ann M Wehman, Didier YR Stainier   +9 more
openaire   +7 more sources