Results 181 to 190 of about 132,111 (275)

Redox‐regulated signalling of adaptations to contractile activity in skeletal muscle: Implications for age‐related muscle weakness

Experimental Physiology, EarlyView.
Abstract Skeletal muscle adaptation to contractile activity is modulated by redox signalling, primarily through reactive oxygen species (ROS) such as hydrogen peroxide (H2O2). Early research framed ROS as deleterious byproducts of exercise, but subsequent studies have established their roles as signalling molecules involved in mitochondrial biogenesis,
Malcolm J. Jackson
wiley   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Tailoring Multiphasic Protein Condensates via Liquid‐Liquid Phase Separation

Aggregate, Volume 7, Issue 4, April 2026.
Multiphasic protein condensates transform structural organizations and deliver nucleic acids. ABSTRACT Many of the membraneless organelles inside cells are multiphasic condensates with complex structural organizations driven by the demixing of phase‐separating proteins.
Yongxu Han, Kai Cheng, Kongqi Chen, Zhiyi Xu, Hao Jiang, Bin Zeng, Manjia Li, Fei Sun, Xiangze Zeng, Sijie Chen, Jiang Xia   +10 more
wiley   +1 more source

Systematic Druggable Genome‐Wide Analysis Identifies Therapeutic Targets for Aging: A Mendelian Randomization Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Currently, there are no effective drug treatments for aging. Mendelian randomization (MR) has been widely applied to repurpose existing drugs and identify new therapeutic targets. Our aim is to identify aging‐related therapeutic targets and evaluate their potential adverse effects, underlying mechanisms, and actionable ...
Yanfang Zhang, Menglong Wang, Hang Li, Ting Jin, Shanshan Peng, Yi Dong, Chaowei Deng, Hang Li, Xinyi Li, Juanjuan Qin, Xujun Ye   +10 more
wiley   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Computational Analysis of Telomerase RNA Evolution in <i>Caenorhabditis</i> Species. [PDF]

Noncoding RNA
Klapproth C, Reinhardt F, Stadler PF, Findeiß S.   +3 more
europepmc   +1 more source

Mycovirus Vector‐Mediated RNAi for Effective Gene Knockdown in Pine Wood Nematodes

Plant Biotechnology Journal, EarlyView.
Ruiling Bian, Yifan Zhang, Zhihao Zhang, Yuchi Bai, Peiqin Li, Guanghui Tang, Lihua Guo, Huan Liu, Ida Bagus Andika, Qiaoxia Shang, Liying Sun   +10 more
wiley   +1 more source

Autophagy‐Independent Function of ATG‐18 Is Essential for Gonadal Longevity in Caenorhabditis elegans

Aging Cell, Volume 25, Issue 4, April 2026.
Neuronal and intestinal ATG‐18 promote longevity conferred by germline removal in C. elegans via non‐autophagic functions. In the intestine, ATG‐18 regulates lifespan through its interaction with the gluconeogenic enzyme PCK‐2. ABSTRACT Autophagy, a highly conserved cellular degradation process, plays essential roles in various physiological processes ...
Tatsuya Shioda, Ittetsu Takahashi, Makoto Horikawa, Taiichi Osumi, Takayuki Shima, Akiyo Yamauchi, Kayo Nakamura, Taeko Sasaki, Tatsuya Kaminishi, Harunori Yoshikawa, Miyuki Sato, Hidetaka Kosako, Tamotsu Yoshimori, Shuhei Nakamura   +13 more
wiley   +1 more source

Genome-wide reconstruction of the intrinsic apoptosis pathway in Haemonchus contortus. [PDF]

BMC Genomics
Shen Y, Young ND, Song J, Sleebs BE, Chang BCH, Lee EF, Fairlie WD, Gasser RB.   +7 more
europepmc   +1 more source