Results 81 to 90 of about 104,016 (302)

The effect of acute caffeine ingestion on upper and lower body anaerobic exercise performance [PDF]

, 2019
The current study examined the effect of acute caffeine ingestion on mean and peak power production, fatigue index and rating of perceived exertion (RPE) during upper body and lower body Wingate anaerobic test (WANT) performance.
Andre T., Borg G., Duncan M. J., Emma Eyre, Green M. J., Jason Tallis, Jozo Grgic, Marlat G. A., Michael J. Duncan, Peterson M. D.   +9 more
core   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Phenotype refinement strengthens the association of AHR and CYP1A1 genotype with caffeine consumption.

PLoS ONE, 2014
Two genetic loci, one in the cytochrome P450 1A1 (CYP1A1) and 1A2 (CYP1A2) gene region (rs2472297) and one near the aryl-hydrocarbon receptor (AHR) gene (rs6968865), have been associated with habitual caffeine consumption.
George McMahon, Amy E Taylor, George Davey Smith, Marcus R Munafò   +3 more
doaj   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Caffeine consumption outcomes on amyotrophic lateral sclerosis disease progression and cognition

Neurobiology of Disease
Caffeine consumption outcomes on Amyotrophic Lateral Sclerosis (ALS) including progression, survival and cognition remain poorly defined and may depend on its metabolization influenced by genetic variants.
Vincent Huin, David Blum, Violette Delforge, Emeline Cailliau, Sofia Djeziri, Kathy Dujardin, Alexandre Genet, Romain Viard, Shahram Attarian, Gaelle Bruneteau, Julien Cassereau, Steeve Genestet, Anne-Laure Kaminsky, Marie-Hélène Soriani, Mathilde Lefilliatre, Philippe Couratier, Sophie Pittion-Vouyovitch, Florence Esselin, Elisa De La Cruz, Nathalie Guy, Ivan Kolev, Philippe Corcia, Pascal Cintas, Claude Desnuelle, Luc Buée, Véronique Danel-Brunaud, David Devos, Anne-Sophie Rolland   +27 more
doaj   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

"Wired," yet intoxicated: modeling binge caffeine and alcohol co-consumption in the mouse [PDF]

, 2014
BACKGROUND: The combination of highly caffeinated "energy drinks" with alcohol (ethanol [EtOH]) has become popular among young adults and intoxication via such beverages has been associated with an elevated risk for harmful behaviors.
Boehm, Stephen L., Companion, Michel, Fritz, Brandon M.   +2 more
core   +1 more source

Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption [PDF]

Pharmacological Reviews, 2018
Most individuals adjust their caffeine intake according to the objective and subjective effects induced by the methylxanthine. However, to reach the desired effects, the quantity of caffeine consumed varies largely among individuals. It has been known for decades that the metabolism, clearance, and pharmacokinetics of caffeine is affected by many ...
openaire   +2 more sources

Toward personalized healthcare: Advances in two‐dimensional nanomaterial‐based flexible electrochemical sensors for physiological monitoring

BMEMat, EarlyView.
This review provides an overview of the properties, composites and application of two‐dimensional (2D) nanomaterials for wearable electrochemical biosensors. Also, the challenges and future prospects of utilizing 2D nanomaterials in wearable electrochemical biosensor applications are discussed.
Kou Zhang, Lu Han, He‐Qing Cai, Xin‐Yu Xue, Yi‐Fei Song, Wu‐Lin Xin, Ying‐Ze Wang, Peng Liu, Juan Liu   +8 more
wiley   +1 more source

Exercise Ameliorates Endocrine Pancreas Damage Induced by Chronic Cola Drinking in Rats [PDF]

, 2016
Purpose: This study evaluates whether the daily practice of an exercise routine might protect from endocrine pancreas damage in cola drinking rats. Methods: Forty-eight Wistar rats were randomly assigned to 4 groups depending on a) beverage consumption ...
Ambrosio, Giuseppe, Azzato, Francisco, Cao, Gabriel Fernando, Gonzalez, Julian, Milei, Jose, Muller, Maria Angelica, Otero-Losada, Matilde Estela, Ottaviano, Graciela Mabel   +7 more
core   +1 more source