Results 81 to 90 of about 204,221 (349)

Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice

Nature Neuroscience, 2016
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths.
P. Langfelder, J. Cantle, Doxa Chatzopoulou, Nan Wang, Fu-Ying Gao, Ismael Al-Ramahi, Xiao-Hong Lu, E. Ramos, Karla El-Zein, Yining Zhao, Sandeep Deverasetty, A. Tebbe, C. Schaab, D. Lavery, D. Howland, Seung Kwak, J. Botas, J. Aaronson, Jim Rosinski, G. Coppola, S. Horvath, X. W. Yang   +21 more
semanticscholar   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System

mBio, 2019
Bacterial type IV secretion systems (T4SSs) have been phylogenetically grouped into two subfamilies. The T4ASSs, represented by the Agrobacterium tumefaciens VirB/VirD4T4SS, include “minimized” machines assembled from 12 VirB- and VirD4-like subunits and
Bo Hu, Pratick Khara, Liqiang Song, Aung Soe Lin, A. Frick-Cheng, M. Harvey, T. Cover, Peter J. Christie   +7 more
semanticscholar   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Metaverse Users' Purchase Intention in Second Life

Journal of Metaverse
The Metaverse is a regenerated digital environment that fully immerses people in a virtual world experience. It is often referred to as the "internet of the future" and has drawn the interest of businesses and academics as well.
Beste Demirci, Murat Gülmez, Eda Yaşa Özeltürkay   +2 more
doaj   +1 more source

Clinical evaluation of myocardial involvement in acute myopericarditis in young adults

BMC Cardiovascular Disorders, 2017
Background Myocardial involvement in young adults has various causes. Acute myopericarditis is one of the myocardial involvements in young adults. It is easy to confuse with acute ST-elevation myocardial infarction because of the electrocardiographic ...
Ersin Saricam, Yasemin Saglam, Tuncay Hazirolan   +2 more
doaj   +1 more source

Sultan Abdülaziz Dönemi Balkanlar’ına İmgesel Bir Bakış: Balkanlaşma Kavramının Ortaya Çıkışına Dair Bir Önerme

Vakanüvis Uluslararası Tarih Araştırmaları Dergisi, 2020
Osmanlı idaresinin bölgede zayıflaması ile Balkanlar yeniden bir inşa sürecine sokuldu. Yeni kavramlar, yeni sınırlar ve yeni tanımlamalar ile sadece Osmanlı sonrası için değil Osmanlı öncesine dairde yeni bir tarih yazılmaya çalışıldı.
Galip ÇAĞ
doaj   +1 more source

Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects.

Cell Reports, 2019
In Huntington disease (HD), the analysis of tissue-specific CAG repeat length effects has been challenging, given the difficulty in obtaining relevant patient tissues with a broad range of CAG repeat lengths. We used genome editing to generate an allelic
Jolene Ooi, S. Langley, Xiao-Hong Xu, K. Utami, Bernice Sim, YiHui Huang, N. Harmston, Yi-Lin Tay, A. Ziaei, R. Zeng, D. Low, F. Aminkeng, Radoslaw M Sobota, F. Ginhoux, E. Petretto, M. Pouladi   +15 more
semanticscholar   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

E-Commerce in EU Countries and Turkey: An Econometric Analysis

Studies in Business and Economics, 2022
Purchase and sale transactions of products and services include trade. Electronic commerce (E-commerce) is expressed as the realization of this process in electronic area.
Oğuz Suzan, Yaşar Dinçer Fatma Cande, Yirmibeşoğlu Gözde   +2 more
doaj   +1 more source