Results 71 to 80 of about 204,221 (349)

Protective effect of chaige anti-alcoholic granules on acute alcoholic liver injury in rats and acute toxicity in mice

Frontiers in Pharmacology
Background and aimAlcoholic liver disease (ALD), caused by consumption of alcohol, with high morbidity and mortality, whose effective interventions is essential.
Ying Chen, Ying Chen, Feiyu Zhao, Feiyu Zhao, Xing Sang, Rongzhen Zhang, Mengfei Bi, Meimei Tang, RongBin Wang, Hongting Wang, Cunqin Wang   +10 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Optimalisasi Pemberdayaan Pelaku Usaha Tenun Cag-Cag Melalui Edukasi Literasi Keuangan

Synergy and Society Service, 2023
The economic growth of a region will indirectly affect the increase or decrease in the number of poverty in that region. One of the factors that can reduce poverty is to encourage and develop the real sector, but there are still many woven fabric craftsmen in Tangkup Village who do not fully understand how to manage a business that is being started ...
null Komang Krishna Yogantara, null Putu Agus Prayogi, null I Putu Agus Suarsana Ariesta, null Sulistyoadi Jokosaharjo, null Gunawan Wibisono, null Made Hedy Wartana, null I Nengah Aristana   +6 more
openaire   +1 more source

Longer CAG repeat length in the androgen receptor gene is associated with premature ovarian failure

, 2009
Background: Premature Ovarian Failure (POF) is a disorder characterized by lack of ovulation and elevated serum gonadotrophin levels before the age of 40 years. The cause of POF in most cases is unknown.
Singh, Rajender, Maitra, Anurupa, Kadam, Seema, Meherji, Pervin, Chatterjee, Suparna, Modi, Deepak, Thangaraj, Kumarasamy   +6 more
core   +1 more source

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

Cyber Academic Group (archived) [PDF]

, 2015
Includes an image of the main page on this date and compressed file containing additional web pages.The Cyber Academic Group (CAG) at the Naval Postgraduate School (NPS) is an interdisciplinary academic partnership providing direction and guidance for ...

core   +2 more sources

Unsupervised Deep Representation Learning and Probabilistic Clustering for the Systems-Level Discovery of Germline Mutation Signatures in Pediatric Cancers

Biomedicines
Background/Aims: While pathogenic germline variants play a critical role in pediatric cancer susceptibility, traditional clinical genetics primarily focuses on single-gene interpretations.
Fahimeh Palizban, Michael E. March, Xiang Wang, James Snyder, Fengxiang Wang, Frank Mentch, Yeshwanth Mahesh, Alexandria Thomas, Deborah J. Watson, Huiqi Qu, John Connolly, Amir Hossein Saeidian, Hassan Vahidnezhad, Joseph Glessner, Hakon Hakonarson   +14 more
doaj   +1 more source

FAN1 modifies Huntington’s disease progression by stabilizing the expanded HTT CAG repeat

Human Molecular Genetics, 2018
Huntington’s disease (HD) is an inherited neurodegenerative disease caused by an expanded CAG repeat in the huntingtin (HTT) gene. CAG repeat length explains around half of the variation in age at onset (AAO) but genetic variation elsewhere in the genome
R. Goold, M. Flower, D. H. Moss, C. Medway, A. Wood‐Kaczmar, R. Andre, Pamela P Farshim, G. Bates, P. Holmans, L. Jones, S. Tabrizi   +10 more
semanticscholar   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Conformational distortions induced by periodically recurring A…A in d(CAG).d(CAG) provide stereochemical rationale for the trapping of MSH2.MSH3 in polyQ disorders

, 2021
CAG repeat instability causes a number of neurodegenerative disorders. The unusual hairpin stem structure formed by the CAG repeats in DNA traps the human mismatch repair MSH2.MSH3 (Mutsβ) complex.
Rathinavelan, T., Yogeeshwar Ajjugal, Thenmalarchelvi Rathinavelan, Ajjugal, Y.   +3 more
core   +1 more source