Results 21 to 30 of about 33,292 (260)
Asian Journal of Andrology, 2014 This study aimed to investigate the correlations among androgen receptor (AR) CAG repeat polymorphism, sex hormones and penile length in healthy Chinese young adult men. Two hundred and fifty-three healthy men (aged 22.8 ± 3.1 years) were enrolled.
Yan-Min Ma +9 more
doaj +1 more source
Androgen Receptor CAG Repeats and Prostate Cancer [PDF]
American Journal of Epidemiology, 2002 Prostate cancer is the most common nonskin malignancy and the second leading cause of cancer deaths among men in the United States. Prostate cancer ([Mendelian Inheritance in Man 176807]) has a complex etiology; presently, age, ethnicity, and family history are the most consistently reported risk factors associated with disease.
Kevin A, Nelson, John S, Witte
openaire +2 more sources
Sexual Medicine, 2018 Background: Testosterone action is mediated through the androgen receptor (AR), whose sensitivity is influenced by the AR CAG repeat polymorphism. However, the relation between late-onset hypogonadism (LOH) and AR CAG repeat length is unclear and studies
Jong Wook Kim, MD, PhD +5 more
doaj +1 more source
Drosophila as a Model of Unconventional Translation in Spinocerebellar Ataxia Type 3
Cells, 2022 RNA toxicity contributes to diseases caused by anomalous nucleotide repeat expansions. Recent work demonstrated RNA-based toxicity from repeat-associated, non-AUG-initiated translation (RAN translation).
Sean L. Johnson +7 more
doaj +1 more source
PolyQ-independent toxicity associated with novel translational products from CAG repeat expansions.
PLoS ONE, 2020 Expanded CAG nucleotide repeats are the underlying genetic cause of at least 14 incurable diseases, including Huntington's disease (HD). The toxicity associated with many CAG repeat expansions is thought to be due to the translation of the CAG repeat to ...
Paige Rudich +2 more
doaj +1 more source
Function of AGCA tetrads in (CAG)n repeats [PDF]
Nucleic Acids Symposium Series, 2004 We investigate the structural properties of d(CAG)n repeats in d[CG(CAG)4CG)]*d[CG(CTG)4CG]. The crystals diffract up to 3.5 A and completeness of data is only 60%. We also measure Tm-UV and CD spectra and gel electrophoresis of this oligomer.
Kazimierz, Grzeskowiak +4 more
openaire +2 more sources
Huntington's Disease with Small
Movement Disorders, 2023 AbstractBackgroundCarriers of small cytosine‐adenine‐guanine (CAG) repeats below 39 in the HTT gene are traditionally associated with milder Huntington's disease, but their clinical profile has not been extensively studied.ObjectiveTo study the phenotype of CAG36‐38 repeat carriers.MethodsWe included 35 patients and premanifest carriers of CAG36‐38 ...
Anna Heinzmann +10 more
openaire +3 more sources
DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases [PDF]
Neurotherapeutics, 2021 CAG repeat expansion is the genetic cause of nine incurable polyglutamine (polyQ) diseases with neurodegenerative features. Silencing repeat RNA holds great therapeutic value. Here, we developed a repeat-based RNA-cleaving DNAzyme that catalyzes the destruction of expanded CAG repeat RNA of six polyQ diseases with high potency.
Nan Zhang +10 more
openaire +2 more sources
Regulation of mRNA translation by MID1: a common mechanism of expanded CAG repeat RNAs
Frontiers in Cellular Neuroscience, 2016 Expansion of CAG repeats, which code for the disease-causing polyglutamine protein, is a common feature in polyglutamine diseases. RNA-mediated mechanisms that contribute to neuropathology in polyglutamine diseases are important. RNA-toxicity describes a
Nadine Griesche +7 more
doaj +1 more source
Frontiers in Psychiatry, 2022 Objective:HTT is a gene containing a key region of CAG repeats. When expanded beyond 39 repeats, Huntington disease (HD) develops. HTT genes with <35 repeats are not associated with HD.
Valentina Moschini +18 more
doaj +1 more source