Results 111 to 120 of about 15,530 (328)

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Simulación y optimización en la logística

Ciencia y Poder Aéreo, 2007
Actualmente, la investigación de operaciones es una herramienta útil en los proceso de diseño, ejecución y control de sistemas logísticos; sin embargo, una de las herramientas mas útiles es la simulación, la cual es una técnica asequible para la solución
Pedro José Sánchez Caimán
doaj   +1 more source

Evidence of cryptic lineages within a small South American crocodilian: the Schneider’s dwarf caiman Paleosuchus trigonatus (Alligatoridae: Caimaninae)

PeerJ, 2019
Schneider’s dwarf caiman Paleosuchus trigonatus is one of the smallest living crocodilians. Due to its broad distribution, cryptic behavior, and small home range, the species is well suited for the study of phylogeographic patterns on a continental scale.
P. Bittencourt, Z. Campos, F. Muniz, Boris Marioni, B. C. Souza, R. Da Silveira, B. de Thoisy, T. Hrbek, I. Farias   +8 more
semanticscholar   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

The dark side of the black caiman: Shedding light on species dietary ecology and movement in Agami Pond, French Guiana.

PLoS ONE, 2019
The black caiman is one of the largest neotropical top predators, which means that it could play a structuring role within swamp ecosystems. However, because of the difficulties inherent to studying black caimans, data are sorely lacking on many aspects ...
Stephane Caut, Vincent Francois, Matthieu Bacques, Daniel Guiral, Jérémy Lemaire, Gilles Lepoint, Olivier Marquis, Nicolas Sturaro   +7 more
doaj   +1 more source

Crocodiles - the Singular Beast in the Renaissance Cabinet

, 2017
Stuffed crocodiles often predominated many famous cabinets, hanging in the center of the ceiling. Crocodilians are the largest reptiles and the largest predator that spends time on land.
Zhang, Peter
core  

The respiratory mechanics of the yacare caiman (Caiman yacare).

The Journal of experimental biology, 2019
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Reichert, Michelle N., Oliveira, Paulo R. C. de, Souza, George M. P. R., Moranza, Henriette G., Restan, Wilmer A. Z., Abe, Augusto S., Klein, Wilfried, Milsom, William K.   +7 more
openaire   +3 more sources

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Efeito do fogo sobre a estrutura e composição da comunidade vegetal em paleo-levees, Pantanal, Brasil

Biodiversidade Brasileira
O Pantanal é um bioma brasileiro dependente do fogo. Tanto o pulso de inundação anual como os eventos de fogo são importantes drivers que condicionam a estrutura das suas formações vegetais.
Rosa Helena da Silva, Alexandre de Matos Martins Pereira, Maxwel Oliveira da Rosa, Anny Grazielly da Silva Arruda, Edna Scremin-Dias, Felipe Augusto Dias , Roberto Luiz Leme Klabin , Mario Buhrke Haberfeld, Luciana Fabbri, Julia de Matos Nogueira, Arnildo Pott, Rafael Arruda, Geraldo Alves Damasceno Junior   +12 more
doaj   +1 more source