Cajal bodies are linked to genome conformation [PDF]
Nature Communications, 2016 Nuclear bodies can nucleate at sites of active transcription and are beneficial for efficient gene expression. Here, the authors show that Cajal bodies, a prominent type of nuclear body, contribute to genome organization with global effects on gene ...
Myong-Hee Sung +2 more
exaly +6 more sources
Nucleus, 2023 The nucleus of higher eukaryotes contains a number of structures that concentrate specific biomolecules and play distinct roles in nuclear metabolism. In recent years, the molecular mechanisms controlling their formation have been intensively studied. In
David Staněk
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Viruses and Cajal Bodies: A Critical Cellular Target in Virus Infection? [PDF]
Viruses, 2023 Nuclear bodies (NBs) are dynamic structures present in eukaryotic cell nuclei. They are not bounded by membranes and are often considered biomolecular condensates, defined structurally and functionally by the localisation of core components.
Lucy Lettin, Bilgi Erbay, G. Eric Blair
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The coilin N-terminus mediates multivalent interactions between coilin and Nopp140 to form and maintain Cajal bodies [PDF]
Nature Communications, 2022 Cajal bodies are membraneless organelles scaffolded by coilin protein. Here, coilin–coilin and coilin–Nopp140 interaction sites are identified and perturbed, revealing coilin’s capacity to form long fibrils and be remodeled into spherical structures.
Edward Courchaine +6 more
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Poly(A) RNAs including coding proteins RNAs occur in plant Cajal bodies. [PDF]
PLoS ONE, 2014 The localisation of poly(A) RNA in plant cells containing either reticular (Allium cepa) or chromocentric (Lupinus luteus, Arabidopsis thaliana) nuclei was studied through in situ hybridisation. In both types of nuclei, the amount of poly(A) RNA was much
Janusz Niedojadło +3 more
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Disruption of ZC3H15 compromises telomere length maintenance by entrapping telomerase within cajal bodies [PDF]
Cell & BioscienceBackground Telomere homeostasis is pivotal in various biological processes including ontogeny, reproduction, physiological aging, and the onset of numerous diseases such as tumors.
Chuanle Wang +12 more
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On the road with WRAP53β: guardian of Cajal bodies and genome integrity [PDF]
Frontiers in Genetics, 2015 The WRAP53 gene encodes both an antisense transcript (WRAP53α) that stabilizes the tumor suppressor p53 and a protein (WRAP53β) involved in maintenance of Cajal bodies, telomere elongation and DNA repair.
Marianne eFarnebo, Sofia eHenriksson
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Quantitative Imaging of MS2-Tagged hTR in Cajal Bodies: Photobleaching and Photoactivation [PDF]
STAR Protocols, 2020 Summary: Advances in imaging technologies, gene editing, and fluorescent molecule development have made real-time imaging of nucleic acids practical. Here, we detail methods for imaging the human telomerase RNA template, hTR via the use of three inserted
Michael Smith +3 more
doaj +2 more sources
Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus [PDF]
, 2017 Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs).
Berciano, Maria T. +7 more
core +4 more sources
VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy [PDF]
Annals of Clinical and Translational Neurology, 2020 Background Distal motor neuropathies with a genetic origin have a heterogeneous clinical presentation with overlapping features affecting distal nerves and including spinal muscular atrophies and amyotrophic lateral sclerosis.
Ana T. Marcos +8 more
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