Results 121 to 130 of about 30,051 (262)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez +6 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2019 Proper repair of DNA double-strand breaks is critical for maintaining genome integrity and avoiding disease. Modification of damaged chromatin has profound consequences for the initial signaling and regulation of repair.
Sofie Bergstrand +3 more
doaj +1 more source
Signal transmission through the dark-adapted retina of the toad (Bufo marinus). Gain, convergence, and signal/noise. [PDF]
, 1990 Responses to light were recorded from rods, horizontal cells, and ganglion cells in dark-adapted toad eyecups. Sensitivity was defined as response amplitude per isomerization per rod for dim flashes covering the excitatory receptive field centers.
Copenhagen, David, Hemilä, S, Reuter, T
core +2 more sources
Income taxes and redistribution in the early twentieth century
The Economic History Review, EarlyView.Abstract This paper examines the distributive effects of personal income taxation in Sweden, the United Kingdom, and the United States during the first half of the twentieth century. We estimate the evolution of marginal and average effective tax rates across the income distribution and calculate the corresponding indices of progressivity and ...
Sara Torregrosa‐Hetland, Oriol Sabaté
wiley +1 more source
European Journal of Histochemistry, 2009 Changes in the organisation of ribosomal genes and nucleolar protein components were analysed in sugarcane (Saccharum officinarum L. cv Cristalina) from the time the quiescent primordia of the radical bands of nodes were stimulated to proliferate by ...
R Acevedo +3 more
doaj +1 more source
Distinction of Neurons, Glia and Endothelial Cells in the Cerebral Cortex: An Algorithm Based on Cytological Features [PDF]
, 2016 The estimation of the number or density of neurons and types of glial cells and their relative proportions in different brain areas are at the core of rigorous quantitative neuroanatomical studies. Unfortunately, the lack of detailed, updated, systematic,
Basilis Zikopoulos +3 more
core +3 more sources
The Journal of Cell Biology, 2002 The Cajal body (CB, formerly coiled body) is a prominent nuclear structure, yet its function remains obscure. Now, Xavier Darzacq, Tamas Kiss (CNRS, Universite Paul Sabatier, Toulouse, France), and colleagues speculate that the CB is where small nuclear RNAs go for modification. Figure Novel guide RNAs localize to CBs.
openaire +2 more sources
Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease
Epilepsia, EarlyView.Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa +17 more
wiley +1 more source
Nopp140-chaperoned 2'-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity. [PDF]
Genes Dev, 2021 Bizarro J +7 more
europepmc +2 more sources
PML bodies in reactive sensory ganglion neurons of the Guillain–Barré syndrome
Neurobiology of Disease, 2004 Acute inflammatory demyelinating polyneuropathy (AIDP) is a type of Guillain–Barré syndrome (GBS) characterized by primary nerve demyelination sometimes with secondary axonal degeneration.
Nuria T Villagrá +6 more
doaj +1 more source