Results 31 to 40 of about 30,051 (262)
Cajal body formation is regulated by coilin SUMOylation [PDF]
Journal of Cell ScienceABSTRACT Cajal bodies (CBs) are membraneless organelles whose mechanism of formation is still not fully understood. Many proteins contribute to the formation of CBs, including Nopp140 (NOLC1), WRAP53 and coilin. Coilin is modified on multiple different lysine residues by SUMO, the small ubiquitin-like modifier.
Sara K. Tucker +2 more
openalex +3 more sources
Dynamic regulation of ARGONAUTE4 within multiple nuclear bodies in Arabidopsis thaliana. [PDF]
PLoS Genetics, 2008 DNA methylation directed by 24-nucleotide small RNAs involves the small RNA-binding protein ARGONAUTE4 (AGO4), and it was previously shown that AGO4 localizes to nucleolus-adjacent Cajal bodies, sites of snRNP complex maturation. Here we demonstrate that
Carey F Li +5 more
doaj +1 more source
Regulation of neuronal differentiation by proteins associated with nuclear bodies. [PDF]
PLoS ONE, 2013 Nuclear bodies are large sub-nuclear structures composed of RNA and protein molecules. The Survival of Motor Neuron (SMN) protein localizes to Cajal bodies (CBs) and nuclear gems.
Benjamin Förthmann +10 more
doaj +1 more source
Imaging of Telomerase RNA by Single-Molecule Inexpensive FISH Combined with Immunofluorescence
STAR Protocols, 2020 Summary: Fluorescent in situ hybridization (FISH) on the RNA moiety of human telomerase (hTR) with 50-mer probes detects hTR RNA accumulated in Cajal bodies.
Emmanuelle Querido +2 more
doaj +1 more source
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández +18 more
wiley +1 more source
The Drosophila melanogaster Cajal body [PDF]
The Journal of Cell Biology, 2006 Cajal bodies (CBs) are nuclear organelles that are usually identified by the marker protein p80-coilin. Because no orthologue of coilin is known in Drosophila melanogaster, we identified D. melanogaster CBs using probes for other components that are relatively diagnostic for CBs in vertebrate cells.
Liu, Ji-Long +5 more
openaire +2 more sources
The Cajal Body and Histone Locus Body [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 The Cajal body (CB) is a nuclear organelle present in all eukaryotes that have been carefully studied. It is identified by the signature protein coilin and by CB-specific RNAs (scaRNAs). CBs contain high concentrations of splicing small nuclear ribonucleoproteins (snRNPs) and other RNA processing factors, suggesting that they are sites for assembly and/
Zehra, Nizami +2 more
openaire +2 more sources
Nature Communications, 2023 Spinal muscular atrophy is an autosomal recessive neuromuscular disease caused by mutations in the multifunctional protein Survival of Motor Neuron, or SMN.
Shaqraa Musawi +15 more
doaj +1 more source
Cajal bodies and snRNPs - friends with benefits. [PDF]
RNA Biol, 2017 Spliceosomal snRNPs are complex particles that proceed through a fascinating maturation pathway. Several steps of this pathway are closely linked to nuclear non-membrane structures called Cajal bodies. In this review, I summarize the last 20 y of research in this field. I primarily focus on snRNP biogenesis, specifically on the steps that involve Cajal
Staněk D.
europepmc +4 more sources