Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells. [PDF]
, 2006 Mutations of the survival motor neuron gene SMN1 cause the inherited disease spinal muscular atrophy (SMA). The ubiquitous SMN protein facilitates the biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs).
Cibert, Christian +5 more
core +3 more sources
TCAB1: Driving telomerase to Cajal bodies [PDF]
Cell Cycle, 2009 Telomerase supports the proliferation of progenitor cells and tumor cells by adding telomere repeats to chromosome ends. The low abundance and restricted expression pattern of telomerase have limited our knowledge of this important enzyme. A new telomerase protein, TCAB1, sheds light on the pathway that governs telomerase holoenzyme assembly and ...
Andrew S, Venteicher, Steven E, Artandi
openaire +2 more sources
A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II [PDF]
, 2014 Cajal bodies are nuclear structures that are involved in biogenesis of snRNPs and snoRNPs, maintenance of telomeres and processing of histone mRNA. Recently, the SUMO isopeptidase USPL1 was identified as a component of Cajal bodies that is essential for ...
Andersen +95 more
core +5 more sources
Nuclear bodies domain changes with microspore reprogramming to embryogenesis
European Journal of Histochemistry, 2009 We analysed the presence of nuclear bodies and particularly Cajal bodies during representative stages of gametophytic and haploid embryogenic development in isolated microspore and anther cultures of a model system (Brassica napus cv.
JM SeguÃ-Simarro +5 more
doaj +1 more source
New clues to the function of the Cajal body [PDF]
EMBO reports, 2002 Small RNA molecules play major roles in a number of cellular functions. Depending on their predominant cellular location, small RNAs have been classified as nuclear (sn), nucleolar (sno) or cytoplasmic (sc). The nucleoplasmic species include the spliceosomal snRNAs (U1, U2, U4, U5 and U6) and the U7 snRNA required for histone pre‐mRNA 3′‐end formation.
Maria Carmo‐Fonseca
openalex +5 more sources
WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models [PDF]
, 2017 SMN (Survival Motor Neuron) deficiency is the predominant cause of spinal muscular atrophy (SMA), a severe neurodegenerative disorder that can lead to progressive paralysis and death.
Bavasso, Francesca +11 more
core +1 more source
Close relation of arterial ICC-like cells to the contractile phenotype of vascular smooth muscle cell [PDF]
, 2007 This work aimed to establish the lineage of cells similar to the interstitial cells of Cajal (ICC), the arterial ICC-like (AIL) cells, which have recently been described in resistance arteries, and to study their location in the artery wall.
Bolton, TB +5 more
core +3 more sources
The Role of Nuclear Bodies in Gene Expression and Disease
Biology, 2013 This review summarizes the current understanding of the role of nuclear bodies in regulating gene expression. The compartmentalization of cellular processes, such as ribosome biogenesis, RNA processing, cellular response to stress, transcription ...
Marie Morimoto, Cornelius F. Boerkoel
doaj +1 more source
Small Cajal Body–specific RNAs ofDrosophilaFunction in the Absence of Cajal Bodies [PDF]
Molecular Biology of the Cell, 2009 During their biogenesis small nuclear RNAs (snRNAs) undergo multiple covalent modifications that require guide RNAs to direct methylase and pseudouridylase enzymes to the appropriate nucleotides. Because of their localization in the nuclear Cajal body (CB), these guide RNAs are known as small CB-specific RNAs (scaRNAs).
Svetlana, Deryusheva, Joseph G, Gall
openaire +2 more sources
A perspective on cortical layering and layer-spanning neuronal elements [PDF]
, 2018 This review article addresses the function of the layers of the cerebral cortex. We develop the perspective that cortical layering needs to be understood in terms of its functional anatomy, i.e., the terminations of synaptic inputs on distinct cellular ...
Larkum, Matthew E. +3 more
core +2 more sources