Keeping up with the condensates: The retention, gain, and loss of nuclear membrane-less organelles
Frontiers in Molecular Biosciences, 2022 In recent decades, a growing number of biomolecular condensates have been identified in eukaryotic cells. These structures form through phase separation and have been linked to a diverse array of cellular processes.
Emma Lacroix +3 more
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Structural basis for dual roles of Aar2p in U5 snRNP assembly [PDF]
, 2013 Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase.
Beggs, J.D. +8 more
core +1 more source
New insights into the classification and nomenclature of cortical GABAergic interneurons. [PDF]
, 2013 A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web ...
A Karagiannis +82 more
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Cells, 2022 Cells possess membraneless ribonucleoprotein (RNP) granules, including stress granules, processing bodies, Cajal bodies, or paraspeckles, that play physiological or pathological roles.
Pureum Jeon +3 more
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In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles [PDF]
, 2002 The NHPX protein is a nucleolar factor that binds directly to a conserved RNA target sequence found in nucleolar box C/D snoRNAs and in U4 snRNA. Using enhanced yellow fluorescent protein (EYFP)– and enhanced cyan fluorescent protein–NHPX fusions, we ...
Lamond, Angus I., Leung, Anthony K. L.
core +5 more sources
In vivo kinetics of Cajal body components [PDF]
The Journal of Cell Biology, 2004 Cajal bodies (CBs) are subnuclear domains implicated in small nuclear ribonucleoprotein (snRNP) biogenesis. In most cell types, CBs coincide with nuclear gems, which contain the survival of motor neurons (SMN) complex, an essential snRNP assembly factor. Here, we analyze the exchange kinetics of multiple components of CBs and gems in living cells using
Dundr, M. +9 more
openaire +3 more sources
Wiring optimization explanation in neuroscience: What is Special about it? [PDF]
, 2019 This paper examines the explanatory distinctness of wiring optimization models in neuroscience. Wiring optimization models aim to represent the organizational features of neural and brain systems as optimal (or near-optimal) solutions to wiring ...
Barberis, Sergio Daniel
core +6 more sources
UsnRNP trafficking is regulated by stress granules and compromised by mutant ALS proteins
Neurobiology of Disease, 2020 Activation of the integrated stress response (ISR), alterations in nucleo-cytoplasmic (N/C) transport and changes in alternative splicing regulation are all common traits of the pathogenesis of Amyotrophic Lateral Sclerosis (ALS).
Simona Rossi +11 more
doaj +1 more source
Resident phenotypically modulated vascular smooth muscle cells in healthy human arteries. [PDF]
, 2012 Vascular interstitial cells (VICs) are non-contractile cells with filopodia previously described in healthy blood vessels of rodents and their function remains unknown.
Greenwood, IA +10 more
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Specific genomic cues regulate Cajal body assembly [PDF]
RNA Biology, 2016 The assembly of specialized sub-nuclear microenvironments known as nuclear bodies (NBs) is important for promoting efficient nuclear function. In particular, the Cajal body (CB), a prominent NB that facilitates spliceosomal snRNP biogenesis, assembles in response to genomic cues.
Iain A, Sawyer +2 more
openaire +2 more sources