The Cajal Body in Plant-Virus Interactions [PDF]
Viruses, 2020 Cajal bodies (CBs) are nuclear membraneless bodies composed of proteins and RNA. Although it is known that CBs play a role in RNA metabolism and the formation of functional ribonucleoprotein (RNP) particles, the whole breadth of CB functions is far from ...
Yi Ding, Rosa Lozano-Durán
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Cajal body proteins differentially affect the processing of box C/D scaRNPs. [PDF]
PLoS ONE, 2015 Small nuclear ribonucleoproteins (snRNPs), which are required for pre-mRNA splicing, contain extensively modified snRNA. Small Cajal body-specific ribonucleoproteins (scaRNPs) mediate these modifications.
Isioma I Enwerem +3 more
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Arabidopsis AGO4 loses its Cajal body localization when heterologously expressed in Nicotiana benthamiana [PDF]
Communicative & Integrative Biology, 2022 In plants, the RNA-directed DNA methylation (RdDM) pathway plays a major role in establishing DNA methylation. At least some components of the RdDM machinery, including the central component AGO4, are known to concentrate in a subnuclear compartment ...
Liping Wang, Rosa Lozano-Duran
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A virus-encoded protein suppresses methylation of the viral genome through its interaction with AGO4 in the Cajal body [PDF]
eLife, 2020 In plants, establishment of de novo DNA methylation is regulated by the RNA-directed DNA methylation (RdDM) pathway. RdDM machinery is known to concentrate in the Cajal body, but the biological significance of this localization has remained elusive. Here,
Liping Wang +5 more
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Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus [PDF]
, 2017 Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs).
O. Tapia +7 more
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Historical first descriptions of Cajal-Retzius cells: from pioneer studies to current knowledge [PDF]
Frontiers in Neuroanatomy, 2014 Santiago Ramón y Cajal developed a great body of scientific research during the last decade of 19th century, mainly between 1888 and 1892, when he published more than 30 manuscripts.
Vanessa eGil +2 more
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On the road with WRAP53β: guardian of Cajal bodies and genome integrity [PDF]
Frontiers in Genetics, 2015 The WRAP53 gene encodes both an antisense transcript (WRAP53α) that stabilizes the tumor suppressor p53 and a protein (WRAP53β) involved in maintenance of Cajal bodies, telomere elongation and DNA repair.
Marianne eFarnebo, Sofia eHenriksson
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UHMK1-dependent phosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells [PDF]
Cell Communication and Signaling, 2022 Resistance to 5-fluorouracil (5-FU) in chemotherapy and recurrence of colorectal tumors is a serious concern that impedes improvements to clinical outcomes.
Huan Niu +6 more
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Cajal’s organization of neuronal nucleus revisited [PDF]
Frontiers in NeuroanatomyIn 1906, Cajal was awarded the Nobel Prize in Physiology or Medicine for his pioneering studies on the structure and organization of nerve centers. Notably, in 1910, Cajal published a seminal work in which he described the essential components of the ...
Miguel Lafarga +5 more
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Correction: WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies. [PDF]
PLoS Biology, 2018 [This corrects the article DOI: 10.1371/journal.pbio.1000521.].
Salah Mahmoudi +7 more
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