Cajal body formation is regulated by coilin SUMOylation. [PDF]
J Cell SciABSTRACT Cajal bodies (CBs) are membraneless organelles whose mechanism of formation is still not fully understood. Many proteins contribute to the formation of CBs, including Nopp140 (NOLC1), WRAP53 and coilin. Coilin is modified on multiple different lysine residues by SUMO, the small ubiquitin-like modifier.
Tucker SK, McLaurin DM, Hebert MD.
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Special focus on the Cajal Body. [PDF]
RNA Biol, 2017 The Cajal body (CB) is a nuclear compartment enriched in specific protein and RNA components without the barrier of a lipid bilayer.
Neugebauer KM.
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WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies. [PDF]
PLoS Biology, 2010 The WRAP53 gene gives rise to a p53 antisense transcript that regulates p53. This gene also encodes a protein that directs small Cajal body-specific RNAs to Cajal bodies.
Salah Mahmoudi +7 more
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UV-induced fragmentation of Cajal bodies [PDF]
The Journal of Cell Biology, 2006 The morphology and composition of subnuclear organelles, such as Cajal bodies (CBs), nucleoli, and other nuclear bodies, is dynamic and can change in response to a variety of cell stimuli, including stress.
Boulon, Severine +3 more
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The Cajal Body Protein WRAP53β Prepares the Scene for Repair of DNA Double-Strand Breaks by Regulating Local Ubiquitination [PDF]
Frontiers in Molecular Biosciences, 2019 Proper repair of DNA double-strand breaks is critical for maintaining genome integrity and avoiding disease. Modification of damaged chromatin has profound consequences for the initial signaling and regulation of repair.
Sofie Bergstrand +3 more
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The Cajal body protein p80-coilin forms a complex with the adenovirus L4-22K protein and facilitates the nuclear export of adenovirus mRNA. [PDF]
mBio, 2023 White L, Erbay B, Blair GE.
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Cajal bodies are linked to genome conformation [PDF]
Nature Communications, 2016 Nuclear bodies can nucleate at sites of active transcription and are beneficial for efficient gene expression. Here, the authors show that Cajal bodies, a prominent type of nuclear body, contribute to genome organization with global effects on gene ...
Qiuyan Wang +9 more
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RNA modification in Cajal bodies [PDF]
RNA Biology, 2016 Aside from nucleoli, Cajal bodies (CBs) are the best-characterized organelles of mammalian cell nuclei. Like nucleoli, CBs concentrate ribonucleoproteins (RNPs), in particular, spliceosomal small nuclear RNPs (snRNPs) and small nucleolar RNPs (snoRNPs).
U. Thomas Meier
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The Impact of Coilin Nonsynonymous SNP Variants E121K and V145I on Cell Growth and Cajal Body Formation: The First Characterization. [PDF]
Genes (Basel), 2020 Yao Y +5 more
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