Results 61 to 70 of about 63,849 (272)
Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies. [PDF]
PLoS Genetics, 2013 Fragile X syndrome is caused by loss of function of a single gene encoding the Fragile X Mental Retardation Protein (FMRP). This RNA-binding protein, widely expressed in mammalian tissues, is particularly abundant in neurons and is a component of ...
Alain Y Dury +6 more
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2008 The Cajal body, originally identified over 100 years ago as a nucleolar accessory body in neurons, has come to be identified with nucleoplasmic structures, often quite tiny, that contain coiled threads of the marker protein, coilin. The interaction of coilin with other proteins appears to increase the efficiency of several nuclear processes by ...
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SMN and coilin negatively regulate dyskerin association with telomerase RNA
Biology Open, 2016 Telomerase is a ribonucleoprotein comprising telomerase RNA and associated proteins. The formation of the telomerase holoenzyme takes place in the Cajal body (CB), a subnuclear domain that participates in the formation of ribonucleoproteins.
Aaron R. Poole, Michael D. Hebert
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Control of echolocation pulses by neurons of the nucleus ambiguus in the rufous horseshoe bat, Rhinolophus rouxi [PDF]
, 1986 1. Horseradish peroxidase was applied by iontophoretic injections to physiologically identified regions of the laryngeal motor nucleus, the nucleus ambiguus in the CF/FM batRhinolophus rouxi. 2.
Rübsamen, R., Schweizer, Hermann
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VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy
Annals of Clinical and Translational Neurology, 2020 Background Distal motor neuropathies with a genetic origin have a heterogeneous clinical presentation with overlapping features affecting distal nerves and including spinal muscular atrophies and amyotrophic lateral sclerosis.
Ana T. Marcos +8 more
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Reduced viability, fertility and fecundity in mice lacking the cajal body marker protein, coilin. [PDF]
PLoS ONE, 2009 BACKGROUND:Coilin is the signature protein of the Cajal body, a conserved nuclear organelle involved in multiple aspects of small ribonucleoprotein (RNP) biogenesis. Coilin is required for Cajal body homeostasis in both plants and animals.
Michael P Walker +2 more
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eLife, 2016 We dissected the importance of human telomerase biogenesis and trafficking pathways for telomere maintenance. Biological stability of human telomerase RNA (hTR) relies on H/ACA proteins, but other eukaryotes use other RNP assembly pathways.
Jacob M Vogan +6 more
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Cajal bodies and coilin—moving towards function [PDF]
The Journal of Cell Biology, 2002 Many nuclear factors are concentrated within nonmembrane-bound subnuclear bodies. The Cajal body is an example of a conserved nuclear compartment that has been linked to molecular disease. Recent studies have shown Cajal bodies to be surprisingly mobile and offer clues about their function in the cell.
Ogg, Stephen C., Lamond, Angus I.
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Advanced Science, EarlyView.Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu +14 more
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Unique Contractile and Structural Protein Expression in Dog Ileal Inner Circular Smooth Muscle [PDF]
, 2009 This study was designed to test the hypothesis that there is heterogeneous expression of contractile and structural proteins between the smooth muscle cells (SMCs) in the inner and outer circular muscle (ICM and OCM) layers of the ileum ...
Eddinger, Thomas J.
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