Results 61 to 70 of about 2,603 (174)

Seasonal variations in calcidiol and parathyroid hormone levels in healthy children and adolescents in Navarre, Spain: a cross-sectional study

JRSM Open, 2016
Objective To analyze the seasonal variations in calcidiol and parathyroid hormone serum levels along a natural year in a paediatric population living in a region of the north of Spain considering a normal nutrition status. Design A cross-sectional study.
Teodoro Durá-Travé, Fidel Gallinas-Victoriano   +1 more
doaj   +1 more source

A single-oral bolus of 100,000 IU of cholecalciferol at hospital admission did not improve outcomes in the COVID-19 disease: the COVID-VIT-D—a randomised multicentre international clinical trial

BMC Medicine, 2022
Background Vitamin D status has been implicated in COVID-19 disease. The objective of the COVID-VIT-D trial was to investigate if an oral bolus of cholecalciferol (100,000 IU) administered at hospital admission influences the outcomes of moderate-severe ...
Jorge B. Cannata-Andía, Augusto Díaz-Sottolano, Pehuén Fernández, Carmen Palomo-Antequera, Pablo Herrero-Puente, Ricardo Mouzo, Natalia Carrillo-López, Sara Panizo, Guillermo H. Ibañez, Carlos A. Cusumano, Carolina Ballarino, Vicente Sánchez-Polo, Jacqueline Pefaur-Penna, Irene Maderuelo-Riesco, Jesús Calviño-Varela, Mónica D. Gómez, Carlos Gómez-Alonso, John Cunningham, Manuel Naves-Díaz, Walter Douthat, José L. Fernández-Martín, the COVID-VIT-D trial collaborators   +21 more
doaj   +1 more source

Integrative Toxicology Profiling of Thuja sutchuenensis Essential Oil: From LD50 Safety Assessment to Hepatic Apoptosis and Gut Microbiota Modulation

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study provides the first experimental evidence of Thuja sutchuenensis essential oil (TEO) toxicity, with an oral LD50 of ~3800 mg/kg in mice. Sub‐LD50 doses cause focal hepatic necrosis via apoptosis/oxidative stress–related pathways without systemic inflammation or renal injury.
Nana Long, Youwei Zuo, Renxiu Yao, Quan Yang, Jian Li, Xiao Zhang, Shiqi You, Yang Peng, Hongping Deng   +8 more
wiley   +1 more source

Genetic Polymorphism of CYP2R1, CYP27A1, CYP27B1, and Vitamin D Metabolites Plasma Levels in Patients with Cardiovascular Disease: A Pilot Study

Biomolecules
The active form of vitamin D, calcitriol (1,25(OH)2D3), is produced from 25(OH)D3 via enzymes encoded by CYP2R1, CYP27A1, and CYP27B1. Polymorphisms in these genes may alter vitamin D metabolism and increase cardiovascular disease risk.
Mohamed Abouzid, Łukasz Kruszyna, Dominika Kaczmarek, Leonid Kagan, Aniceta Ada Mikulska-Sauermann, Dorota Filipowicz, Matylda Resztak, Franciszek K. Główka, Marta Karaźniewicz-Łada   +8 more
doaj   +1 more source

Factors affecting vitamin D status in Moscow adolescents

Медицинский совет, 2019
Justification of the study. The normalization of vitamin D levels in both children and adults is the goal of numerous studies around the world, and the setting of a number of objectives related to this vector of preventive medicine, dictates the need for
I. N. Zakharova, E. A. Solov’yeva, T. M. Tvorogova, S. I. Lazareva, T. Yu. Vil’ken, N. G. Sugyan   +5 more
doaj   +1 more source

Nutritional Deficiencies Following Bariatric Surgery: A Rapid Systematic Review of Case Reports of Vitamin and Micronutrient Deficiencies Presenting More Than Two Years Post‐Surgery

Clinical Obesity, Volume 15, Issue 6, December 2025.
ABSTRACT Bariatric surgery is the most clinically‐ and cost‐effective intervention for severe obesity. However, without adequate follow‐up, it can lead to nutritional deficiencies. Patients require life‐long nutritional supplements and follow‐up to prevent nutritional deficiencies from developing.
Sophie Haughton, Sarah Gentry, Helen M. Parretti   +2 more
wiley   +1 more source

Conservative treatment of bone tissue metabolic disorders among patients with vitamin D-dependent rickets type II with genetic abnormality of type I collagen formation

Bolʹ, Sustavy, Pozvonočnik, 2017
Background. The purpose of the article is to determine the effect of conservative therapy on genetically caused disorders of bone tissue metabolism in patients with vitamin D-dependent rickets type II and genetic abnormality of type I collagen formation (
S.M. Martsyniak
doaj   +1 more source

Vitamin D Deficiency as a Debatable Modulator of Outcomes in Transfusion‐Dependent Thalassemia; An Overview of the Latest Findings: A Narrative Review

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aims Vitamin D deficiency (VDD) is highly prevalent in transfusion‐dependent thalassemia (TDT), yet its clinical implications beyond bone health remain controversial. This review explores the risk factors and clinical outcomes of VDD in TDT, with particular focus on its potential roles in cardiac iron deposition, osteoporosis ...
Ali Bazi, Mahdieh Poodineh Moghadam, Jafar Baranipour, Hajar Noori Sanchooli, Hamed Soleimani Samarkhazan, Omolbanin Sargazi Aval, Mojtaba Aghaei   +6 more
wiley   +1 more source

Vitamin D: A Bridge between Kidney and Heart

Life
Chronic kidney disease (CKD) and cardiovascular disease (CVD) are highly prevalent conditions, each significantly contributing to the global burden of morbidity and mortality. CVD and CKD share a great number of common risk factors, such as hypertension,
Carmine Secondulfo, Valeria Visco, Nicola Virtuoso, Martino Fortunato, Serena Migliarino, Antonella Rispoli, Lucia La Mura, Adolfo Stellato, Giuseppe Caliendo, Emanuela Settembre, Fabiana Galluccio, Sarah Hamzeh, Giancarlo Bilancio   +12 more
doaj   +1 more source

Effect of 25-OH-cholecalciferol supplementation on acute phase reactants, cytokines, and colostrum quality of Holstein cows during the transition period and plasma metabolites of newborn calves

Journal of Dairy Science
: This study investigated the effects of 25-hydroxycholecalciferol (HyD) supplementation on (1) plasma acute phase reactants, cytokines, and Ig concentrations in colostrum in multiparous Holstein cows from 3 wk prepartum to 21 DIM and (2) plasma ...
Saman Lashkari, Mogens Vestergaard, Niels B. Kristensen, Tyler D. Turner, S⊘ren K. Jensen   +4 more
doaj   +1 more source