Effects of Short-Term Calcifediol Supplementation on Leukocyte Cytokine Production in Healthy Dogs: A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial. [PDF]
J Vet Intern MedABSTRACT Background Vitamin D modulates the immune response in many species, including dogs. To date, research investigating the immunological effects of vitamin D in dogs is limited to in vitro studies. Objectives Provide PO calcifediol supplementation to healthy dogs to evaluate its tolerability and assess its effect on leukocyte production of tumor ...
Jaffey JA +4 more
europepmc +2 more sources
Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis. [PDF]
Adv Sci (Weinh)A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Liang Z +9 more
europepmc +2 more sources
Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women: a randomized trial [PDF]
Journal of Bone and Mineral Research, 2021 Vitamin D has shown to play a role in multiple diseases due to its skeletal and extraskeletal actions. Furthermore, vitamin D deficiency has become a worldwide health issue.
Maria Luisa Brandi +2 more
exaly +4 more sources
The seasonality of tuberculosis, sunlight, vitamin D, and household crowding. [PDF]
, 2014 BACKGROUND: Unlike other respiratory infections, tuberculosis diagnoses increase in summer. We performed an ecological analysis of this paradoxical seasonality in a Peruvian shantytown over 4 years. METHODS: Tuberculosis symptom-onset and diagnosis dates
Adams +38 more
core +2 more sources
Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. [PDF]
, 2017 The influence of vitamin D3 and its metabolites calcifediol (25(OH)D) and calcitriol on immune regulation and inflammation is well described, and raises the question of potential benefit against bacterial infections.
Ana Melero +38 more
core +1 more source
25(OH)D3-enriched or fortified foods are more efficient at tackling inadequate vitamin D status than vitamin D3 [PDF]
, 2017 The ability to synthesise sufficient vitamin D through sunlight in human subjects can be limited. Thus, diet has become an important contributor to vitamin D intake and status; however, there are only a few foods (e.g.
Bates +9 more
core +2 more sources
Bariatric surgery: evidence-based practical recommendations [PDF]
, 2008 [Resumen] La obesidad mórbida es, habitualmente, refractaria a los tratamientos convencionales, por lo que la modificación de hábitos dietéticos y de actividad física y/o el uso de fármacos consiguen pérdidas de peso parciales con habitual recuperación ...
Ahmad +174 more
core +2 more sources
Effectiveness of Cinacalcet in Patients with Chronic Kidney Disease and Secondary Hyperparathyroidism Not Receiving Dialysis. [PDF]
, 2017 Background Secondary hyperparathyroidism (SHPT) is a common complication in chronic kidney disease (CKD) patients. Cinacalcet could be a therapeutic option although its use is controversial in patients not receiving dialysis.
Alcalde Rodrigo, Maria +5 more
core +1 more source
Impaired release of Vitamin D in dysfunctional adipose tissue: New cues on Vitamin D supplementation in obesity [PDF]
, 2017 Context: Vitamin D accumulates in adipose tissue (AT) and vitamin D deficiency is frequent in obesity. Objective: We hypothesize that trafficking of vitamin D is altered in dysfunctional AT.
Azzena, Bruno +9 more
core +1 more source
Atypical Bilateral Femur Fractures in a Long-Term Bisphosphonate Therapy: A Case Report [PDF]
, 2015 Atypical Femur Fractures (AFF) are associated with Bisphosphonate Osteoporosis Therapy. Bisphosphonate therapy is widely used as the Gold-Standard Therapy for Osteoporosis: it increases bone density and reduce the risk of vertebral, non-vertebral and hip
Martino, Marcellino +5 more
core +1 more source