Calcifediol: Why, When, How Much? [PDF]
Pharmaceuticals, 2023 Vitamin D deficiency is a constantly growing health problem worldwide. Adults affected with hypovitaminosis D could experience negative consequences on their musculoskeletal system and extra-skeletal health.
Teresa Iantomasi +2 more
exaly +7 more sources
Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis [PDF]
Advanced ScienceElectron transfer (ET) efficiency dictates catalytic performance in multi‐domain self‐sufficient cytochrome P450s. Conventional engineering, however, predominantly focuses on localized optimization of either the active‐site pocket or linker regions ...
Ziqi Liang +9 more
doaj +3 more sources
An open-label interventional study on efficacy and safety of 25 µg of daily calcifediol capsule versus 100 µg of cholecalciferol sachets in apparently healthy volunteers [PDF]
Journal of Nutritional ScienceDespite the multiple advantages of 25-hydroxyvitamin D (calcifediol or 25(OH)D) compared to cholecalciferol, it is used sparingly. This study was planned to assess the safety and efficacy of supplementing daily 25 µg of calcifediol capsules vis-a-vis 100
Ravi Shah +7 more
doaj +2 more sources
Calcifediol Treatment Improves Skin Wound Healing in Vitamin D Deficiency Obese Rats [PDF]
PharmaceuticsBackground/Objectives: Obesity is a major public health problem and a risk factor for numerous diseases. Furthermore, the high prevalence of 25-hydroxyvitamin D (25(OH)D) deficiency in obese individuals promotes a state of persistent inflammation and ...
Bárbara Torrecillas-Baena +9 more
doaj +2 more sources
Rapid and dose-dependent increase of 25(OH)D levels after calcifediol supplementation in a woman with obesity, chronic liver disease, and osteoporosis [PDF]
Archives of Endocrinology and MetabolismVitaminD deficiency is a global concern, and calcifediol serves as an alternative to cholecalciferol for achieving and maintaining optimal vitamin D levels, despite the lack of international guidelines for calcifediol supplementation regimens. We present
Gustavo Kendy Camargo Koga +2 more
doaj +2 more sources
Effects of Short‐Term Calcifediol Supplementation on Leukocyte Cytokine Production in Healthy Dogs: A Randomized, Double‐Blinded, Placebo‐Controlled Crossover Trial [PDF]
Journal of Veterinary Internal MedicineBackground Vitamin D modulates the immune response in many species, including dogs. To date, research investigating the immunological effects of vitamin D in dogs is limited to in vitro studies.
Jared A. Jaffey +4 more
doaj +2 more sources
Vitamin D in the prevention of left ventricular remodelling after an acute myocardial infarction: a randomized clinical trial [PDF]
Scientific ReportsNo clinical trial has yet assessed the effect of vitamin D on patients experiencing ST-segment elevation myocardial infarction (STEMI). In this multicentre, randomised (2:1), double-blind, placebo-controlled trial, 93 patients with anterior STEMI were ...
José Tuñón +27 more
doaj +2 more sources
Randomized trial of activated vitamin D for acute kidney injury prevention in critically ill patients [PDF]
JCI InsightBACKGROUND Active vitamin D metabolites, including 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D), have potent immunomodulatory effects that attenuate acute kidney injury (AKI) in animal models.METHODS We conducted a phase 2, randomized ...
David E. Leaf +11 more
doaj +2 more sources
Cholecalciferol vs. calcifediol supplementation on visceral adiposity in people with obesity: a real-world retrospective study [PDF]
Frontiers in NutritionIntroductionNowadays it is well known that obesity and vitamin D deficiency are closely linked. In this view, this study aimed to assess the effects of two different Vitamin D formulations, combined with a Mediterranean hypocaloric diet (MHD) on 25(OH)D ...
Martina Chiurazzi +9 more
doaj +2 more sources
Vitamin D and chronic kidney disease: mechanisms, clinical implications, and future perspectives [PDF]
Frontiers in MedicineBackgroundVitamin D deficiency is common in chronic kidney disease (CKD). Vitamin D/vitamin D receptor (VDR) signaling intersects inflammation, oxidative stress/mitochondrial injury, fibrogenic pathways, the renin–angiotensin–aldosterone system (RAAS ...
Hong Wang +11 more
doaj +2 more sources