Results 21 to 30 of about 4,418 (175)
Calcifediol Cornerstone of the Vitamin D Endocrine System
Nutrients, 2023 It is likely that rickets has afflicted humanity since the dawn of time, but it was first described in great detail in the mid-17th century [...]
Quesada-Gomez, Jose Manuel +1 more
openaire +2 more sources
Relationships of low serum vitamin Dwith anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity [PDF]
, 2008 Low serum 25 hydroxyvitamin D3 (vitamin D3) is known to perturb cellular function in many tissues, including the endocrine pancreas, which are involved in obesity and type II diabetes mellitus (TIIDM). Vitamin D3 insufficiency has been linked to obesity,
Anne-Thea McGill +37 more
core +3 more sources
Advanced Science, Volume 13, Issue 22, 17 April 2026.Electron Transfer Optimization Strategy Enables Efficient P450‐Mediated Calcifediol Synthesis This cover illustrates a holistic optimization strategy integrating conformational modulation, electron transfer (ET) pathway engineering, and substrate positioning, applied to enhance the ET efficiency of chimeric P450 L21 for calcifediol synthesis.
Ziqi Liang +9 more
wiley +1 more source
Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective
Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.ABSTRACT Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR‘G' subfamily, recent cryo‐EM structures of the androgens 5α‐dihydrotestosterone (5α‐DHT) and methenolone bound to ADGRD1 revealed a putative steroid ...
Bethany Fleming +4 more
wiley +1 more source
Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis? [PDF]
, 2012 Background: Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach.
Barat, Antonio +5 more
core +4 more sources
Optimizing Muscle Health in Sarcopenia With Dietary Supplements: A Narrative Review
JCSM Communications, Volume 9, Issue 1, January/June 2026.ABSTRACT Aims Sarcopenia, the age‐related decline in skeletal muscle mass, strength and functionality, significantly contributes to frailty, falls and disability among older adults, resulting in increased morbidity, mortality and healthcare expenditures.
McKenna W. Box +6 more
wiley +1 more source
Intersections of vitamin D deficiency, HIV and chronic liver diseases
HIV Medicine, Volume 27, Issue 1, Page 4-17, January 2026.Abstract Objectives Despite effective antiretroviral therapy (ART), chronic liver diseases remain a leading cause of morbidity and mortality among people with HIV, with metabolic dysfunction–associated steatotic liver disease (MASLD) now the predominant etiology. Vitamin D deficiency is also highly prevalent in this population.
Francesca Farina +7 more
wiley +1 more source
Vitamin D3 and 25-hydroxyvitamin D3 in pork and their relationship to vitamin D status in pigs [PDF]
, 2016 The content of vitamin D in pork produced in conventional systems depends on the vitamin D concentration in the pig feed. Both vitamin D(3) and 25-hydroxyvitamin D(3) (25(OH)D(3)) are essential sources of dietary vitamin D; however, bioavailability ...
Burild, Anders +4 more
core +2 more sources
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
Clinical Obesity, Volume 15, Issue 6, December 2025.ABSTRACT Bariatric surgery is the most clinically‐ and cost‐effective intervention for severe obesity. However, without adequate follow‐up, it can lead to nutritional deficiencies. Patients require life‐long nutritional supplements and follow‐up to prevent nutritional deficiencies from developing.
Sophie Haughton +2 more
wiley +1 more source