Results 11 to 20 of about 4,051 (202)
Calcifediol: Mechanisms of Action
Nutrients, 2023 Due to its essential role in calcium and phosphate homeostasis, the secosteroid hormone calcitriol has received growing attention over the last few years.
Teresa Iantomasi +2 more
exaly +6 more sources
European Journal of Nutrition, 2023 Background In addition to the role of vitamin D in bone mineralization, calcium and phosphate homeostasis, and skeletal health, evidence suggests an association between vitamin D deficiency and a wide range of chronic conditions.
Claudia Campusano +2 more
exaly +3 more sources
npj VaccinesThe ChAdOx1 nCoV-19 (COVISHIELD) vaccine has emerged as a pivotal tool in the global fight against the COVID-19 pandemic. In our previous study eligible subjects were supplemented with calcifediol, a direct precursor to the biologically active form of ...
Himanshu Singh Saroha +6 more
doaj +3 more sources
Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis [PDF]
Advanced ScienceElectron transfer (ET) efficiency dictates catalytic performance in multi‐domain self‐sufficient cytochrome P450s. Conventional engineering, however, predominantly focuses on localized optimization of either the active‐site pocket or linker regions ...
Ziqi Liang +9 more
doaj +3 more sources
Calcifediol or Corticosteroids in the Treatment of COVID-19: An Observational Study [PDF]
NutrientsMedical treatment of coronavirus 19 disease (COVID-19) is a therapeutic challenge. The available data strongly suggest that calcifediol treatment may reduce the severity of COVID-19, and corticosteroids are the treatment of choice worldwide for severe ...
Cristina Gomez Rebollo +2 more
exaly +3 more sources
Revista de Osteoporosis y Metabolismo Mineral, 2018 Objetivos: Valorar las concentraciones séricas de 25-hidroxivitamina D, 25(OH)D, en pacientes osteoporóticos tratados durante un año con calcifediol. Métodos: Se han estudiado 156 pacientes con osteoporosis (23 varones y 133 mujeres) de 71,9±9,6 años de
Olmos JM +4 more
doaj +4 more sources
Drugs in Context, 2023 As well as being essential for musculoskeletal health, vitamin D is involved in numerous other physiological processes. Poor vitamin D status is linked to a wide range of diseases, including cardiovascular disease, autoimmune conditions, pulmonary ...
Enrique Casado +4 more
doaj +2 more sources
Extended-Release Calcifediol Normalized 1,25-Dihydroxyvitamin D and Prevented Progression of Secondary Hyperparathyroidism in Hemodialysis Patients in a Pilot Randomized Clinical Trial. [PDF]
Am J NephrolIntroduction: Serum concentrations of 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D) decline as chronic kidney disease (CKD) advances, becoming insufficient without effective vitamin D repletion and driving onset of secondary ...
Bishop CW +6 more
europepmc +2 more sources
Geriatrics, 2022 The aim of this single-center, open-label, randomized controlled study was to evaluate which formulation of vitamin D—between cholecalciferol and calcifediol—is most effective in the treatment of hypovitaminosis D in older adults.
Chukwuma Okoye +9 more
doaj +2 more sources
A Randomized Phase II/III Trial Evaluating the Efficacy and Safety of 100 and 125 µg of Calcifediol Weekly Treatment of Severe Vitamin D Deficiency. [PDF]
NutrientsBackground/Objectives: Given the crucial health benefits of vitamin D, addressing severe deficiencies is a pressing medical concern. This study aimed to evaluate the effectiveness and safety of two new weekly doses of calcifediol (100 µg and 125 µg) for ...
Pérez-Castrillón JL +12 more
europepmc +2 more sources