Results 11 to 20 of about 3,013 (168)

A Randomized, Open-Label Study to Assess Efficacy of Weekly Assumption of Cholecalciferol versus Calcifediol in Older Patients with Hypovitaminosis D

Geriatrics, 2022
The aim of this single-center, open-label, randomized controlled study was to evaluate which formulation of vitamin D—between cholecalciferol and calcifediol—is most effective in the treatment of hypovitaminosis D in older adults.
Chukwuma Okoye, Valeria Calsolaro, Filippo Niccolai, Alessia Maria Calabrese, Riccardo Franchi, Sara Rogani, Giulia Coppini, Virginia Morelli, Nadia Caraccio, Fabio Monzani   +9 more
doaj   +1 more source

Calcifediol: Mechanisms of Action

Nutrients, 2023
Due to its essential role in calcium and phosphate homeostasis, the secosteroid hormone calcitriol has received growing attention over the last few years. Calcitriol, like other steroid hormones, may function through both genomic and non-genomic mechanisms.
Simone Donati, Gaia Palmini, Cinzia Aurilia, Irene Falsetti, Francesca Marini, Francesca Giusti, Teresa Iantomasi, Maria Luisa Brandi   +7 more
openaire   +3 more sources

Calcifediol in the management of vitamin D deficiency-related skeletal and extraskeletal diseases: overview and clinical cases

Drugs in Context, 2023
As well as being essential for musculoskeletal health, vitamin D is involved in numerous other physiological processes. Poor vitamin D status is linked to a wide range of diseases, including cardiovascular disease, autoimmune conditions, pulmonary ...
Enrique Casado, Ester Costa, Pedro Mezquita-Raya, Rubén Andújar-Espinosa, José Luis Neyro   +4 more
doaj   +1 more source

Vitamin D Deficiency in Obese Children Is Associated with Some Metabolic Syndrome Components, but Not with Metabolic Syndrome Itself

Metabolites, 2023
Vitamin D deficiency in children is a common nutritional issue in many populations worldwide, associated not only with skeletal malformations but, as recent studies suggest, also with the development of obesity and metabolic syndrome.
Jagoda Hofman-Hutna, Michał Hutny, Edyta Matusik, Magdalena Olszanecka-Glinianowicz, Pawel Matusik   +4 more
doaj   +1 more source

Rapid Nontranscriptional Effects of Calcifediol and Calcitriol

Nutrients, 2022
Classically, a secosteroid hormone, vitamin D, has been implicated in calcium and phosphate homeostasis and has been associated with the pathogenesis of rickets and osteomalacia in patients with severe nutritional vitamin D deficiency. The spectrum of known vitamin D-mediated effects has been expanded in recent years.
Simone Donati, Gaia Palmini, Cinzia Aurilia, Irene Falsetti, Francesca Miglietta, Teresa Iantomasi, Maria Luisa Brandi   +6 more
openaire   +3 more sources

Serum 25‐hydroxyvitamin D concentration and infectious respiratory disease complex in shelter dogs

Journal of Veterinary Internal Medicine, 2021
Background Hypovitaminosis D is a risk factor for the development of respiratory infections in humans and repletion can be protective. Objectives Determine if serum 25‐hydroxyvitamin (OH)D concentrations are lower in shelter dogs and if 25(OH)D ...
Jared A. Jaffey, Michael R. Lappin, Randy Ringold, Rachael Kreisler, Nancy Bradley‐Siemens, Jennifer Hawley, Andrew Sun, Cody Blakeman, Nancy Mayer   +8 more
doaj   +1 more source

Native vitamin D in pre-dialysis chronic kidney disease

Nefrología (English Edition), 2019
Chronic kidney disease patients have a high prevalence of vitamin D insufficiency/deficiency. Vitamin D deficiency has been associated with a variety of bone, metabolic and cardiovascular disorders.
Mariana P. Cardoso, Luciano A.L. Pereira
doaj   +3 more sources

Calcifediol for Use in Treatment of Respiratory Disease

Nutrients, 2022
Calcifediol is the prohormone of the vitamin D endocrine system (VDES). It requires hydroxylation to move to 1,25(OH)2D3 or calcitriol, the active form that exerts its functions by activating the vitamin D receptor (VDR) that is expressed in many organs, including the lungs. Due to its rapid oral absorption and because it does not require first hepatic
Marta Entrenas-Castillo, Lourdes Salinero-González, Luis M. Entrenas-Costa, Rubén Andújar-Espinosa   +3 more
openaire   +3 more sources

Calcifediol During Pregnancy Improves Maternal and Fetal Availability of Vitamin D Compared to Vitamin D3 in Rats and Modifies Fetal Metabolism

Frontiers in Nutrition, 2022
The fetus depends on the transplacental transfer of vitamin D. Calcifediol (25-OH-D3) is the vitamin D metabolite that crosses the placenta. Previously, oral 25-OH-D3 improved serum 25-OH-D3 compared to vitamin D3 in non-pregnant subjects, although no ...
Antonio Gázquez, María Sánchez-Campillo, Alejandro Barranco, Ricardo Rueda, Jia P. Chan, Matthew J. Kuchan, Elvira Larqué   +6 more
doaj   +1 more source

Calcifediol supplementation to reduce pulse pressure in a limited sample of vitamin D deficient older adults with elevated parathyroid hormone levels

Clinical Nutrition Experimental, 2019
Summary: Vitamin D is proposed as an antihypertensive agent, but current evidence is inconclusive. Calcifediol is more potent in raising vitamin D status.
Pol Grootswagers, Anouk M.M. Vaes, Michael Tieland, Lisette C.P.G.M. de Groot   +3 more
doaj   +1 more source