Results 211 to 220 of about 11,230 (296)

Cationic hydrogel with sustained lubrication and anti-calcification for osteoarthritis therapy. [PDF]

J Nanobiotechnology
Sun L, Guo Z, Qin W, Zhang X, Hao D, Zhu W, Han X, Hou Y, Mao L, Lu W, Zhao Y, Jiao K.   +11 more
europepmc   +1 more source

Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcification

, 2006
Robert Terkeltaub
core   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Cutaneous adverse drug reactions in patients with congenital heart disease: a systematic review with focus on perioperative outcomes. [PDF]

BMC Cardiovasc Disord
Javier RM, Salsabila S, Ditsi ESL, Madrik IR, Moelyadi F, Pratiwi AZ, Jonathan, Kosen YD, Simanjuntak IATA, Cita AA, Rahman AA, Berlian AZ, Nugraha MA, Ujianto MA, Gaol TVL, Limanto EJ, Putra APY, Giantambrani CG, Maria A, Bramantyo BB, Rahmatullah AB, Iman NS, Kurniawan K, Aditya MR.   +23 more
europepmc   +1 more source

Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions

, 2010
Atsushi Fukai, Kozo Nakamura, Fumiko Yano, Taku Saito, Fumitaka Kugimiya, Naoshi Ogata, Hiroshi Kawaguchi, Yasushi Oshima, Toshiyuki Ikeda, Ung-Il Chung, Naohiro Kawamura, Akiro Higashikawa   +11 more
core   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Unravelling Marine Benthic Functioning Shifts Under Ocean Acidification. [PDF]

Ecol Lett
Carlot J, Comeau S, Chiarore A, Mirasole A, Alliouane S, Micheli F, Hurd CL, Gattuso JP, Teixidó N.   +8 more
europepmc   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Diffuse bilateral cerebral calcification caused by Vein of Galen aneurysmal malformation in a two-year-old child: A rare presentation. [PDF]

Radiol Case Rep
Tesfaye YM, Solomon DZ, Lakew YF, Tesfaye SM, Alemu MT.   +4 more
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source