Results 221 to 230 of about 11,276 (296)

Caseous Calcification of the Mitral Annulus With Multiple Embolic Strokes. [PDF]

Circ Rep
Ryou C, Kanazawa M, Nishi JI, Yasunaga H, Tashiro H.   +4 more
europepmc   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Diffuse bilateral cerebral calcification caused by Vein of Galen aneurysmal malformation in a two-year-old child: A rare presentation. [PDF]

Radiol Case Rep
Tesfaye YM, Solomon DZ, Lakew YF, Tesfaye SM, Alemu MT.   +4 more
europepmc   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

The Use of Outpatient Diuretics Does Not Impact Somatic Growth in Infants With Bronchopulmonary Dysplasia. [PDF]

Pediatr Pulmonol
Aoyama BC, McGrath-Morrow SA, Collaco JM.   +2 more
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Plaque Progression and Rupture in Obstructive Coronary Artery Disease: A Review of Current Imaging Modalities. [PDF]

Rev Cardiovasc Med
Veneziano FA, Cocco N, Gentile F, Chietera F, De Luca L.   +4 more
europepmc   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Cationic hydrogel with sustained lubrication and anti-calcification for osteoarthritis therapy. [PDF]

J Nanobiotechnology
Sun L, Guo Z, Qin W, Zhang X, Hao D, Zhu W, Han X, Hou Y, Mao L, Lu W, Zhao Y, Jiao K.   +11 more
europepmc   +1 more source