Strategic model reduction by analysing model sloppiness: a case study in coral calcification [PDF]
It can be difficult to identify ways to reduce the complexity of large models whilst maintaining predictive power, particularly where there are hidden parameter interdependencies. Here, we demonstrate that the analysis of model sloppiness can be a new invaluable tool for strategically simplifying complex models.
arxiv +1 more source
Positioning novel biologicals in CKD-mineral and bone disorders [PDF]
Renal osteodystrophy (ROD), the histologic bone lesions of chronic kidney disease (CKD), is now included in a wider syndrome with laboratory abnormalities of mineral metabolism and extra-skeletal calcifications or CKD-mineral and bone disorders (CKD-MBD),
Covic, Adrian+5 more
core +1 more source
STUDY OF PHYSIOLOGICAL AND PATHOLOGICAL BREAST CALCIFICATIONS ON MAMMOGRAPHY [PDF]
INTRODUCTION: Breast calcifications are too small to feel. They can be seen on mammography. They are common and found in about half of all mammograms of females aged 50 and older and one in 10 mammograms of young women. The initial assessment of calcification is made to determine if they confirm well established benign morphologies. Calcifications with
Arera Colony Bhopal+5 more
openaire +1 more source
Emerging PET Tracers in Cardiac Molecular Imaging
18F-fluorodeoxyglucose (FDG) and 18F-sodium fluoride (NaF) represent emerging PET tracers used to assess atherosclerosis-related inflammation and molecular calcification, respectively.
Shashi Bhushan Singh+10 more
doaj +1 more source
Profile of sugammadex for reversal of neuromuscular blockade in the elderly: Current perspectives [PDF]
The number of elderly patients is increasing worldwide. This will have a significant impact on the practice of anesthesia in future decades. Anesthesiologists must provide care for an increasing number of elderly patients, who have an elevated risk of ...
Bertoncello, Francesco+2 more
core +1 more source
The formation of labyrinths, spots and stripe patterns in a biochemical approach to cardiovascular calcification [PDF]
Calcification and mineralization are fundamental physiological processes, yet the mechanisms of calcification, in trabecular bone and in calcified lesions in atherosclerotic calcification, are unclear. Recently, it was shown in in vitro experiments that vascular-derived mesenchymal stem cells can display self-organized calcified patterns.
arxiv +1 more source
Natriuretic peptide receptor-C is up-regulated in the intima of advanced carotid artery atherosclerosis [PDF]
OBJECTIVE: Natriuretic peptide receptor-C (NPR-C/NPR-3) is a cell surface protein involved in vascular remodelling that is up-regulated in atherosclerosis. NPR-C expression has not been well characterized in human carotid artery occlusive lesions.
Abendschein, Dana R+7 more
core +3 more sources
Transurethral ultrasound therapy of the prostate in the presence of calcifications: A simulation study [PDF]
Purpose: Transurethral ultrasound therapy is an investigational treatment modality which could potentially be used for the localized treatment of prostate cancer. One of the limiting factors of this therapy is prostatic calcifications. These attenuate and reflect ultrasound and thus reduce the efficacy of the heating.
arxiv +1 more source
Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantation [PDF]
Relationships of Sclerostin, a bone anti-anabolic protein, with biomarkers of mineral bone disorders in chronic kidney disease are still unsettled, in particular in kidney transplant (KTR).
Farcomeni, Alessio+7 more
core +2 more sources
Extensive calcification in adenocarcinoma of the lung: A case report
Calcification in lung nodules usually indicates a benign lesion. Here, we report the case of a 59‐year‐old male patient with a well defined 30 mm calcified nodule in his right upper lung lobe and calcified mediastinal lymph nodes.
Fumiaki Watanabe+7 more
doaj +1 more source