Results 261 to 270 of about 97,221 (328)

Rimegepant, an Oral Calcitonin Gene–Related Peptide Receptor Antagonist, for Migraine

New England Journal of Medicine, 2019
BACKGROUND Calcitonin gene-related peptide receptor has been implicated in the pathogenesis of migraine. Rimegepant is an orally administered, small-molecule, calcitonin gene-related peptide receptor antagonist that may be effective in acute migraine ...
Richard B Lipton, Gene M Dubowchik, Peter Goadsby   +2 more
exaly   +2 more sources

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The effects of certain TRP channels and voltage-gated KCNQ/Kv7 channel opener retigabine on calcitonin gene-related peptide release in the trigeminovascular system

Cephalalgia, 2022
Background Calcitonin gene-related peptide release in trigeminovascular system is a pivotal component of neurogenic inflammation underlying migraine pathophysiology.
A. Citak, E. Kılınç, I. Torun, S. Ankaralı, Y. Dağıstan, H. Yoldas   +5 more
semanticscholar   +1 more source

The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

Pain, 2017
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the central nervous system. Calcitonin gene–related peptide was found to play
S. Iyengar, M. Ossipov, Kirk W. Johnson
exaly   +2 more sources

The Role of Calcitonin Gene Related Peptide (CGRP) in Neurogenic Vasodilation and Its Cardioprotective Effects

Frontiers in Physiology, 2018
Calcitonin gene-related peptide (CGRP) is a highly potent vasoactive peptide released from sensory nerves, which is now proposed to have protective effects in several cardiovascular diseases.
Zizheng Kee, Susan D Brain
exaly   +2 more sources

Targeting calcitonin gene-related peptide: a new era in migraine therapy

Lancet, The, 2019
Andrew Charles, Patricia Pozo-Rosich
exaly   +2 more sources

A191 THE NEURAL SIGNAL, CALCITONIN GENE-RELATED PEPTIDE (CGRG) ENHANCES A REGULATORY PHENOTYPE IN THE HUMAN IL-4-TREATED MACROPHAGE

Journal of the Canadian Association of Gastroenterology, 2019
Background Interlukin-4 activated human macrophages (M(IL4) promote epithelial wound healing and exert an anti-colitic effect in a murine model. Blood monocyte-derived M(IL4)s from healthy donors and individuals with Crohn’s disease had increased mRNA ...
Jianrong Qiu, Yang Li, Yongchao Jia
semanticscholar   +1 more source

Characterisation of the calcitonin gene-related peptide receptor antagonists ubrogepant and atogepant in human isolated coronary, cerebral and middle meningeal arteries

Cephalalgia, 2020
Background Migraine has been associated with a dysfunctional activation of the trigeminovascular system. Calcitonin gene-related peptide, a neuropeptide released from the trigeminal nerve fibres, has an important role in the pathophysiology of migraine ...
Eloísa Rubio-Beltrán, K. Chan, A. J. Danser, A. Maassenvandenbrink, L. Edvinsson   +4 more
semanticscholar   +1 more source

Calcitonin Gene-Related Peptide Enhances Distraction Osteogenesis by Increasing Angiogenesis

Tissue Engineering. Part A, 2020
Distraction osteogenesis (DO) is a well-established surgical technique for treating bone defect and limb lengthening. The major drawback of DO is the long treatment period as the external fixator has to be kept in place until consolidation is completed ...
Jie Mi, Jiankun Xu, Hao Yao, Xisheng Li, Wenxue Tong, Ye Li, Bingyang Dai, Xuan He, D. H. Chow, Gang Li, Kathy O. Lui, Jie Zhao, L. Qin   +12 more
semanticscholar   +1 more source

Hypersensitivity to Calcitonin Gene–Related Peptide in Post‐Traumatic Headache

Annals of Neurology, 2020
To demonstrate that calcitonin gene–related peptide (CGRP) induces headache exacerbation with migraine‐like features in patients with persistent post‐traumatic headache (PTH) attributed to mild traumatic brain injury (TBI).
Håkan Ashina, Afrim Iljazi, H. M. Al-Khazali, C. E. Christensen, F. Amin, M. Ashina, H. Schytz   +6 more
semanticscholar   +1 more source

Calcitonin and Calcitonin Gene-Related Peptide

1989
The Ca++ ion plays a critical role in neuronal transmission. Therefore, agents capable of modulating it can exert profound effects on the cell’s ability to interpret extracellular signals. In 1964, Hano et al.1 reported that intracisternal Ca++ administration antagonized the action of morphine, which, conversely, was potentiated by the Ca++ chelator ...
Sandra P. Welch, William L. Dewey
openaire   +1 more source