Results 271 to 280 of about 97,221 (328)

The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer

Nature Communications
Neurotransmitters are key modulators in neuro-immune circuits and have been linked to tumor progression. Medullary thyroid cancer (MTC), an aggressive neuroendocrine tumor, expresses neurotransmitter calcitonin gene-related peptide (CGRP), is insensitive
Yingtong Hou, Bo Lin, Tianyi Xu, Juan Jiang, Shuli Luo, Wanna Chen, Xinwen Chen, Yuanqi Wang, Guanrui Liao, Jianping Wang, Jiayuan Zhang, Xuyang Li, Xiao Xiang, Yubin Xie, Ji Wang, Sui Peng, Weiming Lv, Yihao Liu, Haipeng Xiao   +18 more
semanticscholar   +1 more source

History and Review of anti‐Calcitonin Gene‐Related Peptide (CGRP) Therapies: From Translational Research to Treatment

Headache, 2018
Objective – To briefly describe the history of and available data on anti‐calcitonin gene‐related peptide (CGRP) therapies for headache.
S. Tepper
exaly   +2 more sources

Calcitonin gene-related peptide and hypertension

Peptides, 2005
Capsaicin-sensitive sensory nerves participate in the regulation of cardiovascular functions both in the normal state and the pathophysiology of hypertension through the actions of potent vasodilator neuropeptides, including calcitonin gene-related peptide (CGRP).
Pan-Yue, Deng, Yuan-Jian, Li
openaire   +2 more sources

Calcitonin gene-related peptide and migraine

Current Opinion in Neurology, 2015
Migraine is a common, complex disorder of the brain with significant morbidity. As the pathophysiology of the disorder has become better appreciated, the role of neuropeptides has been explored. Calcitonin gene-related peptide (CGRP) has emerged as a promising therapeutic target.CGRP is widely distributed in the nervous system, particularly at ...
Karsan, Nazia, Goadsby, Peter J.
openaire   +3 more sources

Calcitonin gene-related peptide: Novel neuropeptide

Life Sciences, 1986
Calcitonin gene-related peptide (CGRP) is a 37 amino acid peptide encoded in the calcitonin gene. Its expression is dependent on tissue-specific alternative RNA processing: mRNA for CGRP predominates in the brain, whilst calcitonin (CT) mRNA predominates in thyroid C cells.
E C, Goodman, L L, Iversen
openaire   +2 more sources

Differences in pituitary adenylate cyclase-activating peptide and calcitonin gene-related peptide release in the trigeminovascular system

Cephalalgia, 2020
Background Several neurotransmitters are expressed in the neurons of the trigeminal ganglion. One such signalling molecule is the pituitary adenylate cyclase-activating peptide (PACAP).
Jacob C. A. Edvinsson, A. Grell, K. Warfvinge, M. Sheykhzade, L. Edvinsson, K. Haanes   +5 more
semanticscholar   +1 more source

Calcitonin gene-related peptide levels in tear fluid are elevated in migraine patients compared to healthy controls

Cephalalgia, 2019
Background Calcitonin gene-related peptide (CGRP) released from trigeminal nerve fibres indicates trigeminal activation and has a key role in migraine pathophysiology. The trigeminal nerve directly innervates the eye.
K. Kamm, A. Straube, R. Ruscheweyh
semanticscholar   +1 more source

Hypersensitivity to calcitonin gene-related peptide in chronic migraine

Cephalalgia, 2020
Objective To investigate if calcitonin gene-related peptide infusion induces migraine-like attacks in chronic migraine patients. Methods Fifty-eight patients with chronic migraine, either with or without headache on the experimental day, were assessed ...
Afrim Iljazi, Håkan Ashina, Z. Zhuang, Cristina Lopez Lopez, J. Snellman, M. Ashina, H. Schytz   +6 more
semanticscholar   +1 more source

Molecular cloning and expression of equine calcitonin, calcitonin gene-related peptide-I, and calcitonin gene-related peptide-II

Molecular and Cellular Endocrinology, 2003
In this study, we describe the cloning and tissue expression of equine calcitonin (CT), calcitonin-gene related peptide (CGRP)-I, and CGRP-II cDNA. We also describe a novel divergent form of CGRP (CGRP-I). Equine CT has greatest homology (>85%) to human, rat and mouse subgroups of calcitonins.
Ramiro E, Toribio, Catherine W, Kohn, Gustavo W, Leone, Charles C, Capen, Thomas J, Rosol   +4 more
openaire   +2 more sources

Calcitonin Gene Related Peptide

1994
A 37 amino acid peptide which is an alternative product of the calcitonin/CGRP genes, and is expressed in the thyroid and central and peripheral nervous tissue.
openaire   +1 more source