Results 1 to 10 of about 23,587 (266)

Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes [PDF]

Journal of Biomedical Science, 2018
Background Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1).
Ting-Wei Lee, Ting-I Lee, Yung-Kuo Lin, Yu-Hsun Kao, Yi-Jen Chen   +4 more
doaj   +4 more sources

Peptide receptor radionuclide therapy controls inappropriate calcitriol secretion in a pancreatic neuro-endocrine tumor: a case report [PDF]

BMC Gastroenterology, 2020
Background Hypercalcemia of malignancy is not uncommon in patients with advanced stage cancer. In rare cases the cause of the hypercalcemia is excessive production of calcitriol, the active form of vitamin D.
Maarten Haemels, Thierry Delaunoit, Koen Van Laere, Eric Van Cutsem, Chris Verslype, Christophe M. Deroose   +5 more
doaj   +2 more sources

Effect of Calcitriol and Vitamin D Receptor Modulator 2 on Recovery of Injured Skeletal Muscle in Wistar Rats [PDF]

Biomedicines, 2023
Muscle injuries often result in functional limitations due to insufficient healing. This study assessed the influence of calcitriol and vitamin D Receptor Modulator 2 (VDRM2) on muscle regeneration in male Wistar rats following open blunt muscle injury ...
Ioannis Stratos, Svenja Schleese, Ingmar Rinas, Brigitte Vollmar, Thomas Mittlmeier   +4 more
doaj   +2 more sources

The efficacy of calcitriol treatment in non-alcoholic fatty liver patients with different genotypes of vitamin D receptor FokI polymorphism [PDF]

BMC Pharmacology and Toxicology, 2021
Background Vitamin D deficiency is prevalent in patients with non-alcoholic fatty liver disease (NAFLD), but there are debates on the usefulness of vitamin D treatment.
Hamid Yaghooti, Fatemeh Ghanavati, Seyed Saeed Seyedian, Bahman Cheraghian, Narges Mohammadtaghvaei   +4 more
doaj   +2 more sources

A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C [PDF]

, 2012
Background: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C.
Badenhoop, Klaus, Berg, Thomas, Bibert, Stephanie, Bochud, Pierre-Yves, Bojunga, Jörg, Burgisser, Philippe, Cerny, Andreas, Dufour, Jean-François, Geier, Andreas, Gerlach, Tilman J, Heim, Markus H, Kutalik, Zoltan, Lange, Christian M, Malinverni, Raffaele, Moradpour, Darius, Müller, Tobias, Negro, Francesco, Regenass, Stephan, Sarrazin, Christoph, Swiss Hepatitis C Cohort Study Group,, Zeuzem, Stefan   +20 more
core   +17 more sources

The ERRα–VDR axis promotes calcitriol degradation and estrogen signaling in breast cancer cells, while VDR‐CYP24A1‐ERRα overexpression correlates with poor prognosis in patients with basal‐like breast cancer

Molecular Oncology, 2022
Vitamin D is used to reduce cancer risk and improve the outcome of cancer patients, but the vitamin D receptor (VDR; also known as the calcitriol receptor) pathway needs to be functionally intact to ensure the biological effects of circulating calcitriol,
Katia Danza, Letizia Porcelli, Simona De Summa, Roberta Di Fonte, Brunella Pilato, Rosanna Lacalamita, Simona Serratì, Amalia Azzariti, Stefania Tommasi   +8 more
doaj   +1 more source

Anti-Tumor Effects of Ginsenoside 20(S)-Protopanaxadiol and 1,25-Dihydroxyvitamin D3 Combination in Castration Resistant Prostate Cancer

Medicines, 2021
In spite of possessing desirable anticancer properties, currently, limited clinical success has been achieved with 20(S)-protopanaxadiol (aPPD) and 1,25-dihydroxyvitamin D3 (calcitriol).
Mohamed Ben-Eltriki, Subrata Deb, Gehana Shankar, Gray Meckling, Mohamed Hassona, Takeshi Yamazaki, Ladan Fazli, Mei Yieng Chin, Emma S. Tomlinson Guns   +8 more
doaj   +1 more source

Calcitriol and Tacalcitol Modulate Th17 Differentiation Through Osteopontin Receptors: Age-Dependent Insights from a Mouse Breast Cancer Model. [PDF]

Immunotargets Ther
Strzykalska-Augustyniak A, Psurski M, Zachary H, Filip-Psurska B, Kłopotowska D, Milczarek M, Świtalska M, Stachowicz-Suhs M, Łabędź N, Ziemblicka A, Gos M, Wietrzyk J.   +11 more
europepmc   +3 more sources

Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction

Cells, 2022
Background: Increasing evidence indicates that vitamin D deficiency negatively affects the cardiovascular system. Here we studied the therapeutic effects of calcitriol in myocardial infarction (MI) and investigated its underlying mechanisms.
Simin Yang, Chunmiao Wang, Chengshao Ruan, Meiling Chen, Ran Cao, Liang Sheng, Naiying Chang, Tong Xu, Peiwen Zhao, Xuesheng Liu, Fengqin Zhu, Qingzhong Xiao, Shan Gao   +12 more
doaj   +1 more source

Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: a novel approach for breast cancer therapy. [PDF]

PLoS ONE, 2012
Calcitriol antiproliferative effects include inhibition of the oncogenic ether-à-go-go-1 potassium channel (Eag1) expression, which is necessary for cell cycle progression and tumorigenesis.
Janice García-Quiroz, Rocío García-Becerra, David Barrera, Nancy Santos, Euclides Avila, David Ordaz-Rosado, Mariana Rivas-Suárez, Ali Halhali, Pamela Rodríguez, Armando Gamboa-Domínguez, Heriberto Medina-Franco, Javier Camacho, Fernando Larrea, Lorenza Díaz   +13 more
doaj   +1 more source