Results 101 to 110 of about 23,587 (266)

The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
The vitamin D receptor (VDR) regulates hair follicle biology through ligand‐dependent and ligand‐independent mechanisms by heterodimerizing with retinoid X receptor, recruiting coactivator complexes, and activating target genes including Wnt inhibitors, hair keratins, and cell cycle regulators.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

Impaired Insulin sensitivity and Insulin secretion in Haemodialysis patients with and without Secondary Hyperparathyroidism [PDF]

, 2004
The aim of our study was to investigate insulin sensitivity and beta cell function in hemodialysis (HD) patients without diabetes. We hypothesized that parathyroid gland function was a determinant of insulin sensitivity and/or beta cell function.
Gluvic, Zoran M., Komadina, Ljiljana, Milic, Natasa, Perunicic-Pekovic, Gordana, Pljesa, Steva, Rasic-Milutinovic, Zorica   +5 more
core  

Recommendations of the Brazilian Society of Endocrinology and Metabology (SBEM) for the diagnosis and treatment of hypovitaminosis D [PDF]

, 2014
ObjectiveThe objective is to present an update on the diagnosis and treatment of hypovitaminosis D, based on the most recent scientific evidence. Materials and methodThe Department of Bone and Mineral Metabolism of the Brazilian Society of Endocrinology ...
Bandeira, Francisco, Borba, Victoria Zeghbi Cochenski, Borges, João Lindolfo Cunha, Camargo, Marília Brasilio Rodrigues, Lazaretti-Castro, Marise, Maeda, Sergio Setsuo, Silva, Dalisbor Marcelo Weber   +6 more
core   +2 more sources

Lysophosphatidic Acid Synergizes With 1,25‐Dihydroxyvitamin D to Promote Fibroblast Growth Factor‐23 Synthesis via MAPK Signaling and Induction of the IL12A Gene

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Ay et al. investigated the cellular mechanisms behind the role of lysophosphatidic acid (LPA) in FGF23 production. They revealed that LPA cooperates with 1,25‐dihydroxyvitamin D (1,25D), that is, the bioactive form of vitamin D known to stimulate FGF23 synthesis. This synergy entails MAPK signaling and the induction of the gene encoding the interleukin‐
Birol Ay, Sajin Marcus Cyr, Yorihiro Iwasaki, Elizabeth Hill, Eugene P. Rhee, Nevil J. Singh, Petra Simic, Murat Bastepe   +7 more
wiley   +1 more source

Pseudohypoparathyroidism type I-b with neurological involvement is associated with a homozygous PTH1R mutation [PDF]

, 2016
Pseudohypoparathyroidism type 1b (PHP1b) is characterized by hypocalcemia, hyperphosphatemia, increased levels of circulating parathyroid hormone (PTH), and no skeletal or developmental abnormalities.
Almeida, MR, Batista, S, Brás, J, Guerreiro, R, Hardy, J, Oliveira, C, Pires, P, Ribeiro, MH, Santana, I   +8 more
core   +1 more source

A Giant Parathyroid Adenoma Presenting as Coughs and Dyspnea in a Young Woman: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT A parathyroid adenoma is defined as a benign tumor in the parathyroid glands. A type of parathyroid adenoma is giant parathyroid adenoma that weighs > 3.5 g and has a size of more than 2 cm. A 37‐year‐old woman presented with coughs and dyspnea without fever, hemoptysis, and weight loss. Examination of the patient revealed a diffusely enlarged
Somayeh Chahkandi, Nasrin Amiri‐Dashatan, Mehdi Koushki, Mojgan Sanjari   +3 more
wiley   +1 more source

Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression.

PLoS ONE, 2013
During development a tightly controlled signaling cascade dictates the differentiation, maturation and survival of developing neurons. Understanding this signaling mechanism is important for developing therapies for neurodegenerative illnesses.
Rowan P Orme, Manminder S Bhangal, Rosemary A Fricker   +2 more
doaj   +1 more source

The role of vitamin D3 and vitamin B9 (Folic acid) in immune system [PDF]

, 2016
Background and aims: Vitamins are essential constituents of our diet that Longley have been known to influence the immune system. Vitamin D3 and B9 have received particular attention in recent years as these vitamins have been shown to have an unexpected
Mansourabadi, Amir Hossein., Mansouri, Reza., Moogooei, Maryam., Moogooei, Mozhgan., Razavi, Nastaran.   +4 more
core   +1 more source

Pharmacological Management of Secondary Hyperparathyroidism in Patients with Chronic Kidney Disease [PDF]

, 2016
Secondary hyperparathyroidism (SHPT) is a common complication of CKD and is part of the chronic kidney disease-mineral bone disorder (CKD-MBD). SHPT is associated with increased risk of fracture and mortality, thus SHPT control is recommended as kidney ...
Khwaja, A., Salam, S.N., Wilkie, M.E.
core   +1 more source

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei, Mingyue Liuyuan, Zhixin Ye, Xueying Wang, Xueli Zhou, Yifan Shan, Cheng He, Chunting Zhu, Chicheng Zhou, Jingyin Bao, Yonghui Zhang, Gang Chen   +11 more
wiley   +1 more source