Presence and binding characteristics of calcitriol receptors in human fetal gut [PDF]
FEBS Letters, 1990 In the present study, we show for the first time the presence of calcitriol‐specific binding sites in hypertonic extracts of cells isolated from human fetal small intestine and colon from 13–21 weeks of gestation. Woolf plot analysis of the binding characteristics revealed the presence of a single class of high affinity receptors.
Edgard Delvin +3 more
openalex +3 more sources
The role of calcium, calcitriol and its receptors in [PDF]
, 2010 The mechanism of regulation of Parathyroidhormone (PTH)is complex, and diverse factors are involved: the fundamental ones are calcium, calcitriol and phosphorus. Calcium and calcitriol's mechanism of action takes place through its specific receptors, the
Cannata, J.B. (Jorge) +2 more
core +2 more sources
Inhibition of nuclear uptake of calcitriol receptor by uremic ultrafiltrate
Kidney International, 1994 The biological action of calcitriol is mediated through a hormone-receptor complex interacting with nuclear chromatin. Interaction of the calcitriol receptor (VDR) with VDR response elements produces bioactive proteins which carry out the physiological actions of calcitriol.
Sanjeevkumar R. Patel +3 more
openalex +3 more sources
Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases [PDF]
Nutrients, 2022 The global prevalence of eye diseases continues to grow, bringing with it a reduction in the activity levels and quality of life of patients, and partial or complete blindness if left untreated. As such, there is considerable interest in identifying more effective therapeutic options and preventive agents.
Miłosz Caban, Urszula Lewandowska
openalex +3 more sources
Inhibition of calcitriol receptor binding to vitamin D response elements by uremic toxins. [PDF]
Journal of Clinical Investigation, 1995 The genomic action of calcitriol (1,25-dihydroxy-vitamin D3) is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs). Although renal failure is associated with resistance to the action of calcitriol, the mechanism of this resistance is not well understood.
Sanjay R. Patel +4 more
openalex +3 more sources
Effect of glucose on the function of the calcitriol receptor and vitamin D metabolism
Kidney International, 1997 The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes. It has been proposed that chemicals capable of Schiff base formation with the VDR potentially could alter the physiological function of VDR and calcitriol metabolism.
Sanjeevkumar R. Patel +3 more
openalex +3 more sources
Calcitriol-Mediated Hypercalcemia, Somatostatin Receptors Expression and 25-Hydroxyvitamin D3-1α- Hydroxylase in GIST Tumors [PDF]
Frontiers in Endocrinology, 2022 Hypercalcemia is a common complication in cancer patients Mainly caused by Parathyroid hormone-related protein (PTHrP) secretion and metastasis. Calcitriol secretion is a rare source of hypercalcemia in solid tumors, especially in gastrointestinal stromal tumors (GIST).
Yiraldine Herrera‐Martínez +10 more
openalex +5 more sources
The Calcitriol/Vitamin D Receptor System Regulates Key Immune Signaling Pathways in Chronic Lymphocytic Leukemia [PDF]
Cancers, 2021 It has been proposed that vitamin D may play a role in prevention and treatment of cancer while epidemiological studies have linked vitamin D insufficiency to adverse disease outcomes in various B cell malignancies, including chronic lymphocytic leukemia (CLL).
Marina Gerousi +10 more
openalex +4 more sources
Impact of calcitriol and an AKT inhibitor, AT7867, on survival of rat C6 glioma cells
Biotechnology & Biotechnological Equipment, 2021 Glioma is the most prevalent and lethal type of primary tumor of central nervous system. The regulatory role of calcitriol, the active form of vitamin D3, has been determined in various cellular processes including cell survival and apoptosis.
Ozlem Kucukhuseyin +5 more
doaj +1 more source
Effect of glyoxylate on the function of the calcitriol receptor and vitamin D metabolism
Kidney International, 1997 The biological action of calcitriol is mostly mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of target genes. These interactions produce special proteins that carry out the biological activities of calcitriol.
Sanjeevkumar R. Patel +3 more
openalex +3 more sources