Results 221 to 230 of about 23,587 (266)
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Mechanism of decreased intestinal calcitriol receptor concentration in renal failure
American Journal of Physiology-Renal Physiology, 1993The biological actions of calcitriol and its receptor synthesis are believed to be mediated through the calcitriol-receptor complex interacting with nuclear chromatin of target cells. Thus inhibition of the receptor interaction with DNA could diminish the biological actions of calcitriol and upregulation of its receptor.
C H, Hsu, S R, Patel, R, Vanholder
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Calcitriol modulates receptor for advanced glycation end products (RAGE) in diabetic hearts
International Journal of Cardiology, 2014Receptor for advanced glycation end products (RAGE) signaling pathway plays a vital role in diabetic cardiovascular complications. Calcitriol has been shown to exert various beneficial cardiovascular effects. The purpose of this study is to determine whether calcitriol can modulate RAGE expression, and study the potential mechanisms in diabetic hearts ...
Ting-Wei, Lee +5 more
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Journal of Steroid Biochemistry, 1985
In the present study we have examined the developmental changes in the concentration of receptors for calcitriol in high-salt cytosol from the rat testis. Receptors for calcitriol were undetectable (less than 0.4 fmol/mg protein) until day 24, after which there was a rapid increase to reach adult levels (6-8 fmol/mg protein) between day 50-60. The lack
F O, Levy +5 more
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In the present study we have examined the developmental changes in the concentration of receptors for calcitriol in high-salt cytosol from the rat testis. Receptors for calcitriol were undetectable (less than 0.4 fmol/mg protein) until day 24, after which there was a rapid increase to reach adult levels (6-8 fmol/mg protein) between day 50-60. The lack
F O, Levy +5 more
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Acta Endocrinologica, 1992
Vitamin D metabolites in serum and calcitriol receptor concentration in parathyroid tissue were examined in 52 patients operated on for primary hyperparathyroidism. The calcitriol receptor levels were not different in parathyroid adenomas (mean 224 fmol/mg of protein, range 29–509, N = 43), normal parathyroid tissue (mean 245, range 31–690, N = 20 ...
T, Trydal +5 more
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Vitamin D metabolites in serum and calcitriol receptor concentration in parathyroid tissue were examined in 52 patients operated on for primary hyperparathyroidism. The calcitriol receptor levels were not different in parathyroid adenomas (mean 224 fmol/mg of protein, range 29–509, N = 43), normal parathyroid tissue (mean 245, range 31–690, N = 20 ...
T, Trydal +5 more
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Effects of calcitriol upon TGF-βs and their receptors in trophoblast cells
Journal of Reproductive ImmunologyCalcitriol levels increase during pregnancy, contributing to the hormonal and immunological balance, but its deficiency has been associated with problems during this period. Meanwhile, transforming growth factors-β (TGF-βs) play an important role in the maintenance of fetal-maternal immune tolerance; however, exacerbated concentrations of this growth ...
Nancy Noyola-Martínez +8 more
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American Journal of Physiology-Renal Physiology, 1994
The precise localization of the calcitriol (1 alpha,25-dihydroxyvitamin D3) receptor (VDR) and the 25-hydroxyvitamin D3 [25(OH)D3] 24-hydroxylase cytochrome P-450 in the human kidney is unknown. Using newly developed polyclonal antibodies against the human VDR, we demonstrate that the receptor is present in cells of the distal tubule, the collecting ...
R, Kumar +3 more
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The precise localization of the calcitriol (1 alpha,25-dihydroxyvitamin D3) receptor (VDR) and the 25-hydroxyvitamin D3 [25(OH)D3] 24-hydroxylase cytochrome P-450 in the human kidney is unknown. Using newly developed polyclonal antibodies against the human VDR, we demonstrate that the receptor is present in cells of the distal tubule, the collecting ...
R, Kumar +3 more
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Bone, 1990
The content and affinity of calcitriol receptors were analyzed in cultured osteoblasts from normal and hypophosphatemic mice. Hypertonic cell extracts were prepared by sonication followed by centrifugation at 200,000 g x 30 min. Analysis, at saturating levels of labeled 1,25(OH)2D3, revealed that binding of the hormone was dependent on the density of ...
E E, Delvin +4 more
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The content and affinity of calcitriol receptors were analyzed in cultured osteoblasts from normal and hypophosphatemic mice. Hypertonic cell extracts were prepared by sonication followed by centrifugation at 200,000 g x 30 min. Analysis, at saturating levels of labeled 1,25(OH)2D3, revealed that binding of the hormone was dependent on the density of ...
E E, Delvin +4 more
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Endocrinology, 2015
Abstract Vascular calcification (VC) is a degenerative disease that contributes to cardiovascular morbidity and mortality. A negative relationship has been demonstrated between VC and calcium sensing receptor (CaSR) expression in the vasculature.
Aurélien, Mary +8 more
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Abstract Vascular calcification (VC) is a degenerative disease that contributes to cardiovascular morbidity and mortality. A negative relationship has been demonstrated between VC and calcium sensing receptor (CaSR) expression in the vasculature.
Aurélien, Mary +8 more
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Acta Endocrinologica, 1991
Abstract. Since calcitonin stimulates calcitriol production we examined whether a feedback regulatory mechanism exists between these hormones. First, the calcitriol receptor was localized immunocytochemically in cultured TT cells originating from a human thyroid medullary (C-cell) carcinoma.
M, Zabel, M, Dietel
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Abstract. Since calcitonin stimulates calcitriol production we examined whether a feedback regulatory mechanism exists between these hormones. First, the calcitriol receptor was localized immunocytochemically in cultured TT cells originating from a human thyroid medullary (C-cell) carcinoma.
M, Zabel, M, Dietel
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Studies of the Porcine Intestinal Calcitriol Receptor in Pseudo-Vitamin D Deficiency Rickets Type I
Clinical Science, 19901. Calcitriol (1,25-dihydroxyvitamin D3) concentrations in plasma of humans and pigs with pseudo-vitamin D deficiency rickets type I (PVDRI) have been reported to be significantly lower than in normal subjects and animals. Sometimes, however, calcitriol concentrations are relatively high in these subjects and animals (50–80 pmol/l) and nevertheless ...
B, Schröder, R, Kaune, J, Harmeyer
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