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The Effect of Caffeine on Calcitriol-Inducible Vitamin D Receptor-Controlled Gene Expression in Intestinal and Osteoblastic Cells

Calcified Tissue International, 2019
Some epidemiological studies suggested caffeine consumption as the cause for bone mineral density loss. Certain genes involved in this process are regulated by vitamin D receptor (VDR). Therefore, we investigated if caffeine can affect inducible expression of VDR-regulated genes, some of them being involved in bone mineralization process.
Ondřej Ženata, Adéla Marcalíková, Radim Vrzal +2 more
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[Regulation of 1,25(OH)2D3 (calcitriol) receptor by vitamin B6].

Biokhimiia (Moscow, Russia), 1991
In vitamin B6-deficient rats the concentration of in vivo occupied nuclear and total cellular receptors of 1.25(OH)2D3 increases 1.3-1.7 times, whereas the binding of in vitro occupied receptors to DNA-cellulose increases by 40%. Pyridoxal-5'-phosphate (PLP) added in vitro to solubilized receptors of 1.25(OH)2D3 lowers the ligand binding by 15-25% but ...
M N, Sergeev, V B, Spirichev
openaire +1 more source

Calcitriol Prevents In Vitro Vascular Smooth Muscle Cell Mineralization by Regulating Calcium-Sensing Receptor Expression

Endocrinology, 2015
Abstract Vascular calcification (VC) is a degenerative disease that contributes to cardiovascular morbidity and mortality. A negative relationship has been demonstrated between VC and calcium sensing receptor (CaSR) expression in the vasculature.
Aurélien, Mary +8 more
openaire +2 more sources

Effects of calcitriol upon TGF-ΒS and their receptors in trophoblast cells