Impact of calcitriol and an AKT inhibitor, AT7867, on survival of rat C6 glioma cells
Biotechnology & Biotechnological Equipment, 2021 Glioma is the most prevalent and lethal type of primary tumor of central nervous system. The regulatory role of calcitriol, the active form of vitamin D3, has been determined in various cellular processes including cell survival and apoptosis.
Ozlem Kucukhuseyin +5 more
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Vitamin D-metabolic enzymes and related molecules: Expression at the maternal-conceptus interface and the role of vitamin D in endometrial gene expression in pigs. [PDF]
PLoS ONE, 2017 Vitamin D is a secosteroid hormone with many varied functions including regulation of blood calcium levels, cell proliferation, immunity, and reproduction in mammals. Vitamin D is activated by 25-hydroxylase (CYP2R1) and 1-alpha-hydroxylase (CYP27B1) and
Hwanhee Jang +6 more
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Neonatology, surgery and perinatal medicine, 2019 The article presents literature data of the possible role of vitamin D (VD) and polymorphism of the gene of the vitamin D receptors (VDR) in the pathogenetic mechanisms of the formation of pregnancy complications associated with intrauterine infection.
Г. С. Манасова +3 more
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Calcitriol Inhibits Viability and Proliferation in Human Malignant Pleural Mesothelioma Cells
Frontiers in Endocrinology, 2020 Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor, often associated with exposure to asbestos and characterized by poor prognosis and limited treatment options.
Iacopo Gesmundo +11 more
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Analysis of the interaction of calcitriol with the disulfide isomerase ERp57 [PDF]
, 2016 Calcitriol, the active form of vitamin D3, can regulate the gene expression through the binding to the nuclear receptor VDR, but it can also display nongenomic actions, acting through a membrane- associated receptor, which has been discovered as the ...
Altieri, Fabio +7 more
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Scientific Reports, 2023 Fibroblasts play a pivotal role in fibrogenesis after skeletal muscle injury. Excess fibrous formation can disrupt contractile functions and delay functional recovery.
Ratchakrit Srikuea, Muthita Hirunsai
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Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults : research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO) [PDF]
, 2017 Introduction: Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures.
Bertoldo, Francesco +10 more
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Mitochondrial potassium channels: A novel calcitriol target
Cellular & Molecular Biology Letters, 2022 Background Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR).
Anna M. Olszewska +4 more
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A novel model to explain dietary factors affecting hypocalcaemia in dairy cattle [PDF]
, 2011 Most dairy cows exhibit different degrees of hypocalcaemia around calving because the gestational Ca requirements shift to the disproportionately high Ca requirements of lactation.
Martin-Tereso Lopez, J. +1 more
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[The role of calcium, calcitriol and their receptors in parathyroid regulation].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2009 The mechanism of regulation of Parathyroid hormone (PTH) is complex, and diverse factors are involved: the fundamental ones are calcium, calcitriol and phosphorus. Calcium and calcitriol's mechanism of action takes place through its specific receptors, the calcium-sensing receptor (CaR) and the Vitamin D Receptor (VDR). These two factors have an effect
N, Carrillo-López +2 more
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