Results 41 to 50 of about 23,299 (273)

Simultaneous changes in the calcium-sensing receptor and the vitamin D receptor under the influence of calcium and calcitriol [PDF]

Nephrology Dialysis Transplantation, 2008
The regulatory mechanisms of parathyroid hormone (PTH) synthesis are complex, involving calcium, calcitriol, the calcium-sensing receptor (CaR) and the vitamin D receptor (VDR). In this study, the effects of calcium and calcitriol on the simultaneous expression of CaR and VDR mRNA and protein levels were assessed in parathyroid glands cultured in vitro.
Natalia, Carrillo-López, Daniel, Alvarez-Hernández, Ignacio, González-Suárez, Pablo, Román-García, Jose M, Valdivielso, José Luis, Fernández-Martín, Jorge B, Cannata-Andía   +6 more
openaire   +2 more sources

Calcitriol Inhibits HCV Infection via Blockade of Activation of PPAR and Interference with Endoplasmic Reticulum-Associated Degradation

Viruses, 2018
Vitamin D has been identified as an innate anti-hepatitis C virus (HCV) agent but the possible mechanisms for this issue remain unclear. Here, we clarified the mechanisms of calcitriol-mediated inhibition of HCV infection.
Yu-Min Lin, Hung-Yu Sun, Wen-Tai Chiu, Hui-Chen Su, Yu-Chieh Chien, Lee-Won Chong, Hung-Chuen Chang, Chyi-Huey Bai, Kung-Chia Young, Chiung-Wen Tsao   +9 more
doaj   +1 more source

Effect of Schiff base formation on the function of the calcitriol receptor

Kidney International, 1996
The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes. We have shown that the interaction of VDRs with VDREs is inhibited by uremic toxins.
Patel, Sanjeevkumar R., Koenig, Ronald J., Hsu, Chen H.   +2 more
openaire   +2 more sources

Exponentially Increasing Incidences of Cutaneous Malignant Melanoma in Europe Correlate with Low Personal Annual UV Doses and Suggests 2 Major Risk Factors [PDF]

, 2015
For several decades the incidence of cutaneous malignant melanoma (CMM) steadily increased in fair-skinned, indoor-working people around the world. Scientists think poor tanning ability resulting in sunburns initiate CMM, but they do not understand why ...
Akslen LA, Beer TM, Chida K, Cornwell ML, Devgun MS, Dianne E Godar, Eisman JA, Elwood JM, European Commission, Frampton RJ, Godar DE, Köstner K, Madhan Subramanian, Robinson ES, Samira Ashrafi, Stephen J Merrill, Tewari A   +16 more
core   +2 more sources

Evaluation of In Vitro and In Vivo Antiviral Activities of Vitamin D for SARS-CoV-2 and Variants

Pharmaceutics, 2023
The COVID-19 pandemic has brought about unprecedented medical and healthcare challenges worldwide. With the continual emergence and spread of new COVID-19 variants, four drug compound libraries were interrogated for their antiviral activities against ...
Chee-Keng Mok, Yan Ling Ng, Bintou Ahmadou Ahidjo, Zhen Qin Aw, Huixin Chen, Yi Hao Wong, Regina Ching Hua Lee, Marcus Wing Choy Loe, Jing Liu, Kai Sen Tan, Parveen Kaur, De Yun Wang, Erwei Hao, Xiaotao Hou, Yong Wah Tan, Jiagang Deng, Justin Jang Hann Chu   +16 more
doaj   +1 more source

Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models. [PDF]

, 2016
Metabolic syndrome (MetS), characterized as obesity, insulin resistance, and non-alcoholic fatty liver diseases (NAFLD), is associated with vitamin D insufficiency/deficiency in epidemiological studies, while the underlying mechanism is poorly addressed.
Cai, Linbi, Chen, Zishuo, Duan, Zhongping, Han, Yuan-Ping, Hu, Richard, Lai, Yuchen, Liu, Zhenqui, Lugea, Aurelia, Luo, Mei, Nie, Yuanyang, Pandol, Stephen J, Su, Danmei, Sun, Qun, Tsukamoto, Hidekazu, Wu, Guihui, Wu, Pengfei, Xiao, Zhixiong, Zhang, Li, Zheng, Sujun, Zhu, Airu   +19 more
core   +2 more sources

Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with paricalcitol and cinacalcet [PDF]

, 2017
Bone changes related to diabetes have been well stablished, but few strategies have been developed to prevent this growing health problem. In our work, we propose to investigate the effects of calcitriol as well as of a vitamin D analog (paricalcitol ...
Alvarez, Andress, Bergua, Bucking, Chan, Chen, Coyne, Coyne, Coyne, Craig, Cunha, Del Pino-Montes, Devaskar, Elder, Fishbane, Flanagan, Gagnon, Gavaia, Gehling, Goodman, Hamann, Hills, Illien-Junger, Irwin, Jayanarayanan, Jones, Katsumata, Keller, King, Kojima, Kojima, Kojima, Krul-Poel, Lee, Lehner, Lieschke, Lin, Maehata, Moss, Olsen, Pham-Short, Pipino, Pisharath, Pugliese, Rodriguez, Sanguineti, Schutter, Shoben, Sprague, Tsuruta, Tung, Westerfield, Wong, Zhao   +53 more
core   +1 more source

Vitamin D receptor genotype influences parathyroid hormone and calcitriol levels in predialysis patients [PDF]

Kidney International, 1999
BsmI vitamin D receptor (VDR) gene polymorphism has been associated with the severity of hyperparathyroidism in patients on hemodialysis. The aim of this study was to analyze the influence of this polymorphism on parathyroid function and serum calcitriol levels in patients with different degrees of chronic renal failure (CRF) before dialysis.A total of
Marco, Maria Paz, Martínez, Isabel, Amoedo, Maria Luisa, Borràs, Mercè, Saracho, Ramón, Almirall, Jaume, Fibla, Joan, Fernández, Elvira   +7 more
openaire   +2 more sources

Antiproliferative effects of 1,25-dihydroxyvitamin D3 on breast cells: a mini review

Brazilian Journal of Medical and Biological Research, 2002
The hormone 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), the active form of vitamin D3, is an important regulator of calcium homeostasis, exerts antiproliferative effects on various cell systems and can induce differentiation in some kinds of hematopoietic ...
P. Bortman, M.A.A.K. Folgueira, M.L.H. Katayama, I.M.L. Snitcovsky, M.M. Brentani   +4 more
doaj   +1 more source

Androgen Receptor Regulation of Vitamin D Receptor in Response of Castration-Resistant Prostate Cancer Cells to 1 -Hydroxyvitamin D5: A Calcitriol Analog [PDF]

Genes & Cancer, 2010
Calcitriol (1,25(OH)(2)D3) is cytostatic for prostate cancer (CaP), but had limited therapeutic utility due to hypercalcemia-related toxicities, leading to the development of low-calcemic calcitriol analogs. We show that one analog, 1-α-Hydroxyvitamin-D5 (1α(OH)D5), induced apoptosis in castration-sensitive LNCaP prostate cancer cells, but unlike ...
Benjamin A. Mooso, Anisha Madhav, Skyler B. Johnson, Mohana Roy, Mary Moore, Christopher Moy, Grace A. Loredo, Rajendra G. Mehta, Andrew Vaughan, P. Ghosh   +9 more
openalex   +4 more sources