Results 51 to 60 of about 23,299 (273)

Regulation of calcitriol receptor and its mRNA in normal and renal failure rats

Kidney International, 1994
Homologous up-regulation of calcitriol receptor (VDR) by calcitriol is believed to be a transcriptional event. In this experiment, we studied the effect of calcitriol on VDR in normal and renal failure rats. The time course of the effect of calcitriol on VDR mRNA showed a biphasic change in VDR mRNA in response to calcitriol.
Patel, Sanjeevkumar R., Ke, Hui Qiong, Hsu, Chen H.   +2 more
openaire   +2 more sources

Dietary supplementation with calcitriol or quercetin improved eggshell and bone quality by modulating calcium metabolism

Animal Nutrition
This study was aimed to investigate the effects of dietary calcitriol or quercetin supplementation on eggshell and bone quality of laying hens. In trial 1, 72 Hy-Line Brown layers (80-week-old) with weak-shelled strength (25 to 30 N) were assigned into 4
Yu Fu, Jianmin Zhou, Martine Schroyen, Jing Lin, Haijun Zhang, Shugeng Wu, Guanghai Qi, Jing Wang   +7 more
doaj   +1 more source

Calcitriol Alleviates MPP+- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson’s Disease

Frontiers in Aging Neuroscience, 2021
The pathogenesis of Parkinson’s disease (PD) is currently unclear. Recent studies have suggested a correlation between vitamin D and PD. Vitamin D and its analogs have protective effects in animal models of PD, but these studies have not clarified the ...
Junjie Hu, Jiawei Wu, Fang Wan, Liang Kou, Sijia Yin, Yadi Sun, Yunna Li, Qiulu Zhou, Tao Wang   +8 more
doaj   +1 more source

Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by Campylobacter jejuni [PDF]

, 2019
Campylobacter jejuni (C. jejuni) is the most common cause of foodborne gastroenteritis worldwide. The bacteria induce diarrhea and inflammation by invading the intestinal epithelium. Curcumin is a natural polyphenol from turmeric rhizome of Curcuma longa,
Bereswill, Stefan, Butkevych, Eduard, Bücker, Roland, Fromm, Anja, Golz, Julia C., Heimesaat, Markus M., Kehrenberg, Corinna, Kittler, Sophie, Lobo de Sá, Fábia Daniela, Moos, Verena, Mousavi, Soraya, Nattramilarasu, Praveen Kumar, Schulzke, Jörg-Dieter, Seinige, Diana, Stingl, Kerstin   +14 more
core   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Calcitriol affects hCG gene transcription in cultured human syncytiotrophoblasts

Reproductive Biology and Endocrinology, 2008
Background In pregnancy, maternal serum concentrations of calcitriol significantly rise as a result of increased renal and placental contribution in order to assure calcium supply for the developing fetus.
Díaz Lorenza, Morales Angélica, Larrea Fernando, Halhali Ali, González Leticia, Méndez Isabel, Hernández Guillermo, Avila Euclides, Barrera David   +8 more
doaj   +1 more source

Vitamin D. a dynamic molecule. how relevant might the dynamism for a vitamin be [PDF]

, 2015
Cholecalciferol, the precursor of Vitamin D3, is a very old, highly conserved, molecule. Its presence is evident in non-mineralized 750 million-year-old living species, such as plankton.
Mazzaferro, Sandro, Pasquali, Marzia
core   +2 more sources

Putative helices 3 and 5 of the human vitamin D₃ receptor are important for the binding of calcitriol [PDF]

FEBS Letters, 1998
We have introduced eleven point mutations into the human vitamin D receptor by site‐directed mutagenesis in order to identify some of the amino acid residues that are important for ligand binding. The amino acid residues Ser225, His229, Asp232, Val234, Ser235, Tyr236, Ser237, Lys240, Ile242, Lys246 (helix 3), and Ser275 (helix 5) of the human vitamin D
Väisänen, Sami, Rouvinen, Juha, Mäenpää, Pekka H   +2 more
openaire   +2 more sources

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells

Redox Biology, 2019
Purpose: The activation of ROS-NLRP3-IL-1β signaling axis induced by hyperosmotic stress (HS) has been recognized as a key priming stage of epithelial inflammation in dry eye pathogenesis.
Yiqin Dai, Jing Zhang, Jun Xiang, Yue Li, Dan Wu, Jianjiang Xu   +5 more
doaj   +1 more source