Results 71 to 80 of about 23,299 (273)

Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment

Contemporary Oncology, 2017
Aim of the study: Vitamin D receptor (VDR) expression and serum vitamin D scores in oral premalignant lesions and oral cancer have not been widely analyzed. The role of vitamin D supplementation in advanced oral cancer for improving quality of life (QOL)
Akshay Anand, Suyash Singh, Abhinav A. Sonkar, Nuzhat Husain, Kul Ranjan Singh, Sudhir Singh, Jitendra K. Kushwaha   +6 more
doaj   +1 more source

PTH suppression by calcitriol does not predict off‐target actions in experimental CKD

Pharmacology Research & Perspectives, 2020
Vitamin D receptor agonist (VDRA) therapy for PTH suppression is a mainstay for patients with severe CKD. Calcitriol (1,25‐(OH)2D3) is a former first‐line VDRA in CKD treatment.
Bruno A. Svajger, Cynthia M. Pruss, Kimberly J. Laverty, Jason G. E. Zelt, Glenville Jones, Martin Kaufmann, Martin Petkovich, Rachel M. Holden, Michael A. Adams   +8 more
doaj   +1 more source

Chronic calcitriol supplementation improves the inflammatory profiles of circulating monocytes and the associated intestinal/adipose tissue alteration in a diet-induced steatohepatitis rat model. [PDF]

PLoS ONE, 2018
Vitamin D deficiency and up-regulated TNFα-related signals are reported to be involved in abnormalities including intestinal hyper-permeability, bacterial translocation, systemic/portal endotoxemia, intestinal/adipose tissue/hepatic inflammation, and ...
Yen-Bo Su, Tzu-Hao Li, Chia-Chang Huang, Hung-Cheng Tsai, Shiang-Fen Huang, Yun-Cheng Hsieh, Ying-Ying Yang, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin   +9 more
doaj   +1 more source

Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight [PDF]

, 2016
Despite clear associations between vitamin D deficiency and obesity and/or type 2 diabetes, a causal relationship is not established. Vitamin D receptors (VDRs) are found within multiple tissues, including the brain.
Arble, Deanna M., Chambers, Adam P., Gardner, David, Gutierrez-Aguilar, Ruth, He, Yanlin, Moore, David D., Sandoval, Darleen A., Seeley, Randy J., Sisley, Stephanie R., Xu, Yong   +9 more
core   +4 more sources

Functional Calcitriol/Vitamin D Receptor Signaling in Chronic Lymphocytic Leukemia

Blood, 2019
Calcitriol, the biologically active form of vitamin D, modulates a plethora of cellular processes following its receptor ligation, namely the vitamin D receptor (VDR), a nuclear transcription factor that regulates the transcription of diverse genes.
Marina Gerousi, Fotis Psomopoulos, Kostantia Kotta, Niki Stavroyianni, Achilles Anagnostopoulos, Ioannis Kotsianidis, Stavroula Ntoufa, Kostas Stamatopoulos   +7 more
openaire   +1 more source

Vitamin D‐induced mechanisms in cancer prevention and therapy: Recent advances and future opportunities

Animal Models and Experimental Medicine, EarlyView.
Vitamin D, traditionally known to promote calcium and bone health, is being explored for its role in cancer prevention and treatment through its influence on cell proliferation, differentiation, apoptosis, and immune response. The vitamin D receptor (VDR) regulates gene expression and interacts with key signaling pathways such as Wnt/β‐catenin, MAPK ...
D. Prasanth, Pathan Amanulla Khan, Jamal‐E‐Fatima, Trupti Pratik Durgawale, Falak Arjumand Siddique, Sharuk L. Khan, Azmath Farhana, Uttam Prasad Panigrahy, Mohammed Abdul Aziz shahid, Mohammed Sayeed, Md. Faysal   +10 more
wiley   +1 more source

Molecular aspects of intestinal calcium absorption [PDF]

, 2015
Intestinal Ca2+ absorption is a crucial physiological process for maintaining bone mineralization and Ca2+ homeostasis. It occurs through the transcellular and paracellular pathways.
Díaz de Barboza, Gabriela, Guizzardi, Solange Natali, Tolosa, Nori Graciela   +2 more
core   +1 more source

Vitamin D Receptor mRNA Measured in Leukocytes with the TaqMan Fluorogenic Detection System: Effect of Calcitriol Administration [PDF]

Clinical Chemistry, 2004
AbstractBackground: The aim of the present study was to investigate the interactions between the circulating concentrations of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and the mRNA concentration of its specific nuclear receptor in human leukocytes.Methods: We measured vitamin D receptor (VDR) mRNA extracted from leukocytes by use of TaqMan fluorescence ...
Soldati L, Adamo D, Bianchin C, Arcidiacono T, Terranegra A, Bianchi ML, Mora Stefano, Cusi D, Vezzoli G   +8 more
openaire   +3 more sources

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

The Investigation of the Effects of Calcitriol on Human Ovarian Carcinoma Cells

Ahi Evran Medical Journal
Purpose: Ovarian cancer is the fifth leading cause of cancer death in women, leading cause of death from gynecologic malignancies, and the second most commonly diagnosed gynecologic malignancy, however the underlying pathophysiology is not clearly ...
10.46332/aemj.1228216, Ebru Alimoğulları   +1 more
doaj   +1 more source