Results 101 to 110 of about 3,468,317 (412)

Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting

open access: yesJournal of Immunology Research, 2015
Neutrophils participate in the maintenance of host integrity by releasing various cytotoxic proteins during degranulation. Due to recent advances, a major role has been attributed to neutrophil-derived cytokine secretion in the initiation, exacerbation ...
Isabelle Naegelen   +5 more
doaj   +1 more source

Mild-intensity physical activity prevents cardiac and osseous iron deposition without affecting bone mechanical property or porosity in thalassemic mice

open access: yesScientific Reports, 2022
Thalassemia causes anemia, ineffective erythropoiesis, bone loss and iron accumulation in several tissues, e.g., liver, bone and heart, the last of which leads to lethal cardiomyopathy and arrhythmia. Although exercise reportedly improves bone density in
Narattaphol Charoenphandhu   +12 more
doaj   +1 more source

Multiscale studies of delayed afterdepolarizations II: Calcium-overload-induced ventricular arrhythmias [PDF]

open access: yesarXiv, 2023
Disturbances in calcium homeostasis in a cardiac myocyte can lead to calcium-overload conditions and abnormal calcium releases, which occur primarily in the following two phases of the action potential (AP): (a) triggered or late calcium release (LCR) during the plateau phase; (b) spontaneous calcium release (SCR) during the diastolic interval (DI ...
arxiv  

Involvement of Protein Kinase C and Protein Kinase A in the Enhancement of L-type Calcium Current by GABA\u3csub\u3eB\u3c/sub\u3e Receptor Activation in Neonatal Hippocampus [PDF]

open access: yes, 2011
In the early neonatal period activation of GABAB receptors attenuates calcium current through N-type calcium channels while enhancing current through L-type calcium channels in rat hippocampal neurons.
Bray, Jennifer Grace, Mynlieff, Michelle
core   +1 more source

Renal control of calcium, phosphate, and magnesium homeostasis.

open access: yesAmerican Society of Nephrology. Clinical Journal, 2015
Calcium, phosphate, and magnesium are multivalent cations that are important for many biologic and cellular functions. The kidneys play a central role in the homeostasis of these ions. Gastrointestinal absorption is balanced by renal excretion. When body
J. Blaine, M. Chonchol, M. Levi
semanticscholar   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

open access: yesFEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra   +7 more
wiley   +1 more source

Regulation of reactivated elongation in lysed cell models of teleost retinal cones by cAMP and calcium. [PDF]

open access: yes, 1986
Teleost retinal cones elongate in the dark and contract in the light. In isolated retinas of the green sunfish Lepomis cyanellus, cone myoids undergo microtubule-dependent elongation from 5 to 45 micron. We have previously shown that cone contraction can
Ackland, N, BURNSIDE, Beth, Gilson, C
core   +1 more source

The Calcium Phosphate−Calcium Carbonate System: Growth of Octacalcium Phosphate on Calcium Carbonates [PDF]

open access: yes, 2011
The kinetics of nucleation and crystal growth of octacalcium phosphate [Ca8(PO4)6H2·5H2O, OCP] from calcium phosphate supersaturated solutions inoculated with seed crystals was investigated at 37 °C, pH 7.40, at conditions of constant solution ...
Combes, Christèle   +2 more
core   +1 more source

Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.

open access: yesNew England Journal of Medicine, 1997
BACKGROUND Inadequate dietary intake of calcium and vitamin D may contribute to the high prevalence of osteoporosis among older persons. METHODS We studied the effects of three years of dietary supplementation with calcium and vitamin D on bone mineral
B. Dawson-Hughes   +3 more
semanticscholar   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

open access: yesFEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause   +2 more
wiley   +1 more source

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