Results 61 to 70 of about 3,468,317 (412)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Three-Dimensional Model of Sub-Plasmalemmal Ca2+ Microdomains Evoked by T Cell Receptor/CD3 Complex Stimulation

Frontiers in Molecular Biosciences, 2022
Ca2+ signalling plays an essential role in T cell activation, which is a key step to start an adaptive immune response. During the transition from a quiescent to a fully activated state, Ca2+ microdomains of reduced spatial and temporal extents develop ...
Diana Gil, Björn-Philipp Diercks, Andreas H. Guse, Geneviève Dupont   +3 more
doaj   +1 more source

Regulation of intracellular cyclic GMP concentration by light and calcium in electropermeabilized rod photoreceptors. [PDF]

, 1994
This study examines the regulation of cGMP by illumination and by calcium during signal transduction in vertebrate retinal photoreceptor cells. We employed an electropermeabilized rod outer segment (EP-ROS) preparation which permits perfusion of low ...
Coccia, V J, Cote, Rick H.
core   +2 more sources

The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential

Pharmacological Reviews, 2015
Voltage-gated calcium channels are required for many key functions in the body. In this review, the different subtypes of voltage-gated calcium channels are described and their physiologic roles and pharmacology are outlined. We describe the current uses
G. Zamponi, J. Striessnig, A. Koschak, A. Dolphin   +3 more
semanticscholar   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca2+-dependent inactivation

Nature Communications, 2016
Timothy Syndrome (TS) is a multisystem disorder caused by two mutations leading to dysfunction of the CaV1.2 channel. Here, Dick et al. uncover a major and mechanistically divergent effect of both mutations on Ca2+/calmodulin-dependent inactivation of ...
Ivy E. Dick, Rosy Joshi-Mukherjee, Wanjun Yang, David T. Yue   +3 more
doaj   +1 more source

Impact of calcium on salivary α-amylase activity, starch paste apparent viscosity and thickness perception [PDF]

, 2011
Thickness perception of starch-thickened products during eating has been linked to starch viscosity and salivary amylase activity. Calcium is an essential cofactor for α-amylase and there is anecdotal evidence that adding extra calcium affects ...
A Kumari, AAD Comrie, AC Alting, AD Nielsen, AL Ferry, ALS Ferry, Andrew J. Taylor, AR Nazmi, BL Vallee, Cecile Morris, CF Gonzalez, CI Heinzerling, D Suvd, DS Bush, E Bertoft, E Salvolini, G Muralikrishna, ID Evans, J Hsiu, J Kivela, J Lin, JGL Harrison, JW Woolnough, L Engelen, L Sewon, LS Collado, M Machius, M O’Mahony, M Tietz, MJ Larsen, RA Wijk de, RG Schipper, Susanne L. Fichtel, WM Edgar   +33 more
core   +1 more source

The Activity of Calcium in Calcium-Calcium Halide Fluxes.

ISIJ International, 1996
The activities of calcium in the CaOsatd.-Ca-CaX2 fluxes (X: Cl, Br, I) were measured as a function of the calcium composition at 1 473 K by equilibrating these fluxes with a solid zirconium plate. The activities decreased in the order CaCl2, Cal2 and CaBr2 at the same calcium fraction of these fluxes.
Ken-ichi Mori, Fumitaka Tsukihashi, Nobuo Sano, Tomoyasu Ogasawara, Teruo Tominaga   +4 more
openaire   +3 more sources

Calcium in the blood [PDF]

Experimental Biology and Medicine, 1921
In our continued investigation of the calcium in the blood we have paid particular attention to furunculosis and to diabetes. The results here published are part of over 225 determinations made on human beings with the method described by Kramer and Tisdall.1 They state the normal is 9.2—11.1 mg. in 100 c.c. of blood.In a previous paper2 we showed that
Thro, W. C., Ehn, M.
openaire   +3 more sources

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, EarlyView.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source